The World Health Organization recommended name for albuterol base is salbutamol.

Inhalation Aerosol

The active component of this formulation is albuterol racemic (a¹-[(tert-butylamino)methyl]-4-hydroxy-m-xylene-a, a¢-diol) and a relatively selective beta₂-adrenergic bronchodilator. The molecular weight is 239.3 and the empirical formula is C₁₃H₂₁NO₃. Albuterol is a white to off-white crystalline solid. It is soluble in ethanol, sparingly soluble in water, and very soluble in chloroform.

Ventolin inhalation aerosol is a pressurized metered-dose aerosol unit for oral inhalation. It contains a microcrystalline (95% £10 mm) suspension of albuterol in propellants (trichloromonofluoromethane and dichlorodifluoromethane) with oleic acid. Each actuation delivers 100 mcg of albuterol from the valve and 90 mcg of albuterol from the mouthpiece. Each 6.8-g canister provides 80 inhalations and each 17-g canister provides 200 inhalations.

Inhalation Solutions and Capsules for Inhalation

The active component in these albuterol inhalation formulations is albuterol sulfate, the racemic form of albuterol and a relatively selective beta₂-adrenergic bronchodilator. It has the chemical name (a¹-[(tert-butylamino)methyl]-4-hydroxy-m-xylene-a, a¢-diol) (2:1)(salt). Albuterol sulfate has a molecular weight of 576.7 and the empirical formula is C₁₃H₂₁NO₃·H₂SO₄. Albuterol sulfate is a white crystalline powder, soluble in water and slightly soluble in ethanol.

Ventolin Inhalation Solution, 0.5%: Ventolin inhalation solution, 0.5% is in concentrated form. Dilute the appropriate volume of the solution (see DOSAGE AND ADMINISTRATION) with sterile normal saline solution to a total volume of 3 ml and administer by nebulization. Each milliliter of Ventolin inhalation solution contains 5 mg of albuterol (as 6 mg of albuterol sulfate) in an aqueous solution containing benzalkonium chloride; sulfuric acid is used to adjust the pH to between 3 and 5. Ventolin inhalation solution contains no sulfiting agents and is a clear, colorless to light yellow solution.

Ventolin Nebules Inhalation Solution, 0.083%: Ventolin Nebules inhalation solution requires no dilution before administration by nebulization. Each milliliter of Ventolin Nebules inhalation solution contains 0.83 mg of albuterol (as 1 mg of albuterol sulfate) in an isotonic, sterile, aqueous solution containing sodium chloride; sulfuric acid is used to adjust the pH to between 3 and 5. Ventolin Nebules inhalation solution contains no sulfiting agents or preservatives and is a clear, colorless solution.

Ventolin Rotacaps: Ventolin Rotacaps for inhalation contain a dry powder presentation of albuterol sulfate intended for oral inhalation only. Each light blue and clear, hard gelatin capsule contains a mixture of 200 mcg of microfine (95% £10 mm) albuterol (as the sulfate) with 25 mg of lactose. The contents of each capsule are inhaled using a specially designed plastic device for inhaling powder called the Rotahaler. When turned, this device opens the capsule and facilitates dispersion of the albuterol sulfate into the airstream created when the patient inhales through the mouthpiece. Ventolin Rotacaps for inhalation are an alternative inhalation form of albuterol to the metered-dose pressurized inhaler.

CATEGORIES, BRAND NAMES

CATEGORIES: Asthma; Pregnancy Category C; FDA Approval Pre 1982; Patent Expiration 2014 Feb; Top 200 Drugs; WHO Formulary

FDA Drug Classes: Antiasthmatics/Broncodilators

BRAND NAMES:

BRAND NAMES: Aerolin; Airet; Airomir; Albuterol Sulfate; Almotex; Anebron; Asmadil; Asmalin; Asmanil; Asmasal; Asmatol; Asmaven; Asmavent; Asmidon; Asmol Uni-Dose; Asthalin; Broncho-Spray; Broncovaleas; Bronter; Bugonol; Butamol; Buto-Asma; Butotal; Buventol; Cobutolin; Dilatamol; Farcolin; Grafalin; Instavent; Libretin; Medolin; Mozal; Novosalmol; Parasma; Proventil; Respax; Salbetol; Salbron; Salbulin; Salbusian; Salbutalan; Salbutamol; Salbutan; Salbutol; Salbuven; Salbuvent; Salmaplon; Salomol; Sedalin; Sultanol; Suprasma; Theosal; Tobybron; Vencronyl; Venetlin; Ventilan; Ventimax; Ventolin; Ventoline; Ventolin Rotacaps; Volmax
(Foreign Brand names outside U.S. in italics)

FOREIGN BRAND AVAILABILITY:
Aerolin (Brazil; Chile; Greece)
Airomir (Australia; Canada; France; Philippines; Thailand)
Almotex (Philippines)
Asmadil (Benin; Burkina-Faso; Ethiopia; Gambia; Ghana; Guinea; Ivory-Coast; Kenya; Liberia; Malawi; Mali; Mauritania; Mauritius; Morocco; Niger; Nigeria; Senegal; Seychelles; Sierra-Leone; Sudan; Tanzania; Tunia; Uganda; Zambia; Zimbabwe)
Asmasal (Thailand)
Asmatol (Argentina)
Asmaven (England)
Asmidon (Japan)
Asmol Uni-Dose (New-Zealand)
Asthalin (India)
Broncho-Spray (Germany; South-Africa)
Broncovaleas (Italy)
Bronter (Colombia)
Bugonol (Colombia)
Buto-Asma (Spain)
Butotal (Chile)
Cobutolin (England)
Dilatamol (Indonesia)
Farcolin (Bahrain; Cyprus; Egypt; Iran; Iraq; Israel; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic-of-Yemen; Saudi-Arabia; Syria; United-Arab-Emirates)
Grafalin (Indonesia)
Libretin (Philippines)
Medolin (Thailand)
Mozal (Taiwan)
Novosalmol (Canada)
Parasma (Colombia)
Respax (Australia; New-Zealand)
Salbetol (India)
Salbron (Indonesia)
Salbulin (Costa-Rica; Dominican-Republic; El-Salvador; England; Guatemala; Honduras; Panama)
Salbutalan (Mexico)
Salbutan (Venezuela)
Salbutol (Korea; Peru)
Salbuven (Indonesia)
Salbuvent (Norway)
Salmaplon (India)
Salomol (Taiwan)
Sedalin (Philippines)
Sultanol (Austria; Germany; Japan)
Suprasma (Indonesia)
Tobybron (Indonesia)
Vencronyl (Philippines)
Venetlin (Japan)
Ventilan (Colombia; Portugal)
Ventoline (Denmark; Finland; France; Norway; Sweden)

Administration route: INHALATION.