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Alendronate sodium is an aminobisphosphonate
that acts as a specific inhibitor of osteoclast-mediated bone
resorption. Bisphosphonates are synthetic analogs of pyrophosphate
that bind to the hydroxyapatite
found in bone.
Alendronate sodium is chemically
described as (4-amino-1- hydroxybutylidene) bisphosphonic acid
monosodium salt trihydrate.
The empirical formula
of alendronate sodium
and its formula weight
Alendronate sodium is a white,
crystalline, nonhygroscopic powder. It is soluble
in water, very slightly soluble
in alcohol, and practically insoluble in chloroform.
Fosamax Tablets for oral administration
contain either 6.53, 13.05 mg or 52.21 mg
of alendronate monosodium
salt trihydrate, which is the
molar equivalent of 5.0, 10.0 mg
and 40.0 mg, respectively, of free acid, and the following inactive ingredients:
cellulose, anhydrous lactose, croscarmellose sodium, and magnesium
CATEGORIES, BRAND NAMES
CATEGORIES: Osteoporosis; Paget's disease; FDA Class 1P
("Priority Review"); FDA Approved 1995 Sep; Top 200 Drugs; Pregnancy
FDA Drug Classes: Calcium Metabolism
BRAND NAMES: Alend; Bifosa; Eucalen; Fosalan;
Fosamax; Indrol; Mavil; NeoBon; Osteovan
(Foreign Brand names outside U.S. in italics)
FOREIGN BRAND AVAILABILITY: