Each mL of CELESTONE SOLUSPAN* Injectable Suspension contains: 3.0 mg
betamethasone as betamethasone sodium phosphate; 3.0 mg betamethasone
acetate; 7.1 mg dibasic sodium phosphate; 3.4 mg monobasic sodium phosphate;
0.1 mg edetate disodium; and 0.2 mg benzalkonium chloride. It is a sterile,
aqueous suspension with a pH between 6.8 and 7.2.
The formula for betamethasone sodium phosphate is C22H28FNa2O8P
with a molecular weight of 516.41. Chemically it is 9-Fluoro-11b,
The formula for betamethasone acetate is C24H31FO6with
a molecular weight of 434.50. Chemically it is 9-Fluoro-11b,
Betamethasone sodium phosphate is a white to practically white, odorless
powder, and is hygroscopic. It is freely soluble in water and in methanol,
but is practically insoluble in acetone and in chloroform.
Betamethasone acetate is a white to creamy white, odorless powder that
sinters and resolidifies at about 165C, and remelts at about 200C-220C
with decomposition. It is practically insoluble in water, but freely soluble
in acetone, and is soluble in alcohol and in chloroform.