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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (M's) » Midodrine



DESCRIPTION

ProAmatine® (midodrine hydrochloride) Tablets

WARNING: Because ProAmatine® can cause marked elevation of supine blood pressure, it should be used in patients whose lives are considerably impaired despite standard clinical care. The indication for use of ProAmatine® in the treatment of symptomatic orthostatic hypotension is based primarily on a change in a surrogate marker of effectiveness, an increase in systolic blood pressure measured one minute after standing, a surrogate marker considered likely to correspond to a clinical benefit. At present, however, clinical benefits of ProAmatine®, principally improved ability to carry out activities of daily living, have not been verified.


Name: ProAmatine® (midodrine hydrochloride) Tablets

Dosage Form: 2.5-mg and 5-mg tablets for oral administration

Active Ingredient: Midodrine hydrochloride, 2.5 mg or 5 mg

Inactive Ingredients: Microcrystalline Cellulose NF, Colloidal Silicone Dioxide NF, Magnesium Stearate NF, Corn Starch NF, Talc USP, FD& C Yellow No. 6 Lake (5-mg tablet).

Pharmacological Classification: Vasopressor/Antihypotensive

Chemical Names (USAN): (Midodrine Hydrochloride):

(1) Acetamide, 2-amino-N-[2-(2,5dimethoxyphenyl)-2-hydroxyethyl]-monohydrochloride,(±)-;

(2) (±)-2-amino-N-(b-hydroxy-2,5-dimethoxyphenethyl) acetamide monohydrochloride BAN, INN, JAN: Midodrine

Molecular Formula: C12H18N2O4 · HCl;

Molecular Weight: 290.7

Organoleptic Properties: Odorless, white, crystalline powder

Solubility:

Water: Soluble
Methanol: Sparingly soluble

pKa: 7. 8 (0.3% aqueous solution)

pH: 3.5 to 5.5 (5% aqueous solution)

Melting Range: 200 to 203° C





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