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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (O's) » Octreotide (Injection)



DESCRIPTION

Sandostatin® (octreotide acetate) Injection, a cyclic octapeptide prepared as a clear sterile solution of octreotide, acetate salt, in a buffered lactic acid solution for administration by deep subcutaneous (intrafat) or intravenous injection. Octreotide acetate, known chemically as L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[2-hydroxy-1( hydroxymethyl)propyl)-, cyclic( 2> 7)-disulfide;[R-( R*,R*)] acetate salt, is a long-acting octapeptide with pharmacologic actions mimicking those of the natural hormone somatostatin.

Sandostatin® (octreotide acetate) Injection is available as: sterile 1 mL ampuls in 3 strengths, containing 50, 100, or 500 mcg octreotide (as acetate), and sterile 5 mL multi-dose vials in 2 strengths, containing 200 and 1000 mcg/mL of octreotide (as acetate).

Each ampul also contains:

lactic acid, USP   3.4 mg
mannitol, USP   45 mg
sodium bicarbonate, USP   qs to pH 4.2 0.3
water for injection, USP   qs to 1 mL

Each mL of the multi-dose vials also contains:

lactic acid, USP   3.4 mg
mannitol, USP   45 mg
phenol, USP   5.0 mg
sodium bicarbonate, USP   qs to pH 4.2 0.3
water for injection, USP   qs to 1 mL

Lactic acid and sodium bicarbonate are added to provide a buffered solution, pH to 4.2 0.3.

The molecular weight of octreotide acetate is 1019.3 (free peptide, C49H66N10O10S2).





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