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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (O's) » Octreotide



DESCRIPTION

Octreotide is the acetate salt of a cyclic octapeptide. It is a long-acting octapeptide with pharmacologic properties
mimicking those of the natural hormone somatostatin. Octreotide is known chemically as L-Cysteinamide, D-phenylalanyl- L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[2-hydroxy-1-(hydroxymethyl) propyl]-, cyclic (2_7)-disulfide; [R-(R*,R*)].

Sandostatin LAR® Depot is available in a vial containing the sterile drug product, which when mixed with diluent,
becomes a suspension that is given as a monthly intragluteal injection. The octreotide is uniformly distributed within the microspheres which are made of a biodegradeable glucose star polymer, D,L-lactic and glycolic acids copolymer. Sterile mannitol is added to the microspheres to improve suspendability.

Sandostatin LAR® Depot is available as: sterile 5 mL vials in 3 strengths delivering 10 mg, 20 mg or 30 mg octreotide free peptide. Each vial of Sandostatin LAR® Depot delivers:


Name Of Ingredient 10 mg 20 mg 30 mg
Octreotide acetate 11.2 mg* 22.4 mg* 33.6 mg*
D, L- lactic and glycolic acids

copolymer

188.8 mg 377.6 mg 566.4 mg
Mannitol 41.0 mg 81.9 mg 122.9 mg
*Equivalent to 10/ 20/ 30 mg octreotide base.
Each vial of diluent contains:
carboxymethylcellulose sodium 10.0 mg
mannitol 12.0 mg
water for injection 2.0 mL


The molecular weight of octreotide is 1019.3 (free peptide, C49H66N10O10S2)





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