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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (O's) » Ofloxacin (ophthalmic)



DESCRIPTION

OCUFLOX® (ofloxacin ophthalmic solution) 0.3% is a sterile ophthalmic solution. It is a fluorinated carboxyquinolone anti-infective for topical ophthalmic use.

Chemical Name: (±)-9-Fluoro-2,3-dihydro-3-methyl-iO-(4-methyl-1-piperazinyl)-7-oxo- 7H-pyrido[1,2,3-de]-1,4 benzoxazine-6-carboxylic acid.

Empirical Formula: C18H20FN3O4 .

Molecular Weight: 361.37.

Contains:
Active: Ofloxacin 0.3% (3 mg/ mL)
Preservative: benzalkonium chloride 0.005%;
Inactives: sodium chloride and purified water. May also contain hydrochloric acid and/or sodium hydroxide to adjust pH.

OCUFLOX® solution is unbuffered and formulated with a pH of 6.4 (range - 6.0 to 6.8). It has an osmolality of 300 mOsm/kg. Ofloxacin is a fluorinated 4-quinolone which differs from other fluorinated 4-quinolones in that there is a six member (pyridobenzoxazine) ring from positions 1 to 8 of the basic ring structure.





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