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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (O's) » Olsalazine



DESCRIPTION

Dipentum (brand of olsalazine sodium capsules)

The active ingredient in DIPENTUM Capsules (olsalazine sodium) is a sodium salt of salicylate, disodium 3,3' -azobis (6-hydroxybenzoate) a compound that is effectively bioconverted to 5-aminosalicylic acid (5-ASA), which has anti-inflammatory activity in ulcerative colitis. Its empirical formula is C14H8N2Na2O6 with a molecular weight of 346.21.

Olsalazine sodium is a yellow crystalline powder which melts with decomposition at 240°C. It is the sodium salt of a weak acid, soluble in water and DMSO, and practically insoluble in ethanol, chloroform and ether. Olsalazine sodium has acceptable stability under acidic or basic conditions.

DIPENTUM is supplied in hard gelatin capsules for oral administration. The inert ingredient in each 250 mg capsule of olsalazine sodium is magnesium stearate. The capsule shell has the following inactive ingredients: black iron oxide, caramel, gelatin, and titanium dioxide.





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