|Physicians planning to use penicillamine should thoroughly
familiarize themselves with its toxicity, special dosage considerations,
and therapeutic benefits. Penicillamine should never be used casually.
Each patient should remain constantly under the close supervision
of the physician. Patients should be warned to report promptly any
symptoms suggesting toxicity.
Penicillamine is a chelating agent used in the treatment of Wilson's
disease. It is also used to reduce cystine excretion in cystinuria and
to treat patients with severe, active rheumatoid arthritis unresponsive
to conventional therapy (see INDICATIONS).
It is 3-mercapto-D-valine. It is a white or practically white, crystalline
powder, freely soluble in water, slightly soluble in alcohol, and insoluble
in ether, acetone, benzene, and carbon tetrachloride. Although its configuration
is D, it is levorotatory as usually measured:
calculated on a dried basis.
||= - 62.5 ± 2 (c = 1, 1N NaOH),
The empirical formula is C5H11NO2S,
giving it a molecular weight of 149.21.
It reacts readily with formaldehyde or acetone to form a thiazolidine-carboxylic
Capsules CUPRIMINE® (Penicillamine) for oral administration contain
either 125 mg or 250 mg of penicillamine. Each capsule contains the following
inactive ingredients: D & C Yellow 10, gelatin, lactose, magnesium stearate,
and titanium dioxide. The 125 mg capsule also contains iron oxide.