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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (P's) » Penicillin G Benzathine


Bicillin L-A (penicillin G benzathine suspension) is prepared by the reaction of dibenzylethylene diamine with two molecules of penicillin G. It is chemically designated as (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylic acid compound with N,N-dibenzylethylene diamine (2:1), tetrahydrate.

It is available for deep intramuscular injection. It contains penicillin G benzathine in aqueous suspension with sodium citrate buffer and, as w/v, approximately 0.5% lecithin, 0.6% carboxymethylcellulose, 0.6% povidone, 0.1% methylparaben, and 0.01% propylparaben. It occurs as a white, crystalline powder and is very slightly soluble in water and sparingly soluble in alcohol.

Bicillin L-A suspension in TUBEX® formulation is viscous and opaque. It is available in 1 mL and 2 mL TUBEX Sterile Cartridge-Needle Units containing the equivalent of 600,000 units and 1,200,000 units respectively of penicillin G as the benzathine salt. See CONTRAINDICATIONS, WARNINGS, PRECAUTIONS, and DOSAGE AND ADMINISTRATION sections prior to use.

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