DESCRIPTION

Penicillin V potassium is the potassium salt of penicillin V. This chemically improved form combines acid stability with immediate solubility and rapid absorption. It is designated 4-thia-1-azabicyclo[3.2.0]-heptane-2-carboxylic acid, 3,3 -dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-, monopotassium salt, [2S-(2a,5a,6b)]-. The empirical formula is C₁₆H₁₇KN₂O₅S, and the molecular weight is 388.48.

Each tablet contains penicillin V potassium equivalent to 250 mg (400,000 units) or 500 mg (800,000 units) penicillin V. The tablets also contain lactose, magnesium stearate, povidone, starch, stearic acid, and other inactive ingredients.

After being mixed as directed, each 5 ml of the oral solution will contain penicillin V potassium equivalent to 250 mg (400,000 units) penicillin V. The suspension also contains citric acid, F D & C Red No. 40, flavors, saccharin, sodium citrate, and sucrose.

The potassium content of the tablets and oral solution is listed below (TABLE 1).

CATEGORIES, BRAND NAMES

CATEGORIES: Chorea, prevention; Endocarditis, prevention, secondary to tooth extraction; Erysipelas; Infection, skin and skin structures; Infection, upper respiratory tract; Rheumatic fever, prophylaxis; Scarlet fever; Vincent's gingivitis; Vincent's pharyngitis; Pregnancy Category B; FDA Approved 1957 Sep; Top 200 Drugs; WHO Formulary

FDA Drug Classes: Penicillins

BRAND NAMES:

BRAND NAMES: Abbocillin VK; Acipen; Anapenil; Apsin VK; Apo-Pen-VK; Arcasin; Asillin; Beapen; Beepen-Vk; Betapen-Vk; Calciopen; Cilacil; Cilicaine; Cilicaine VK; Cliacil; Compocillin; Compocillin VK; Crystapen V; Distaquaine V-K; DuraPenicillin; Fenocin; Fenospen; Fenoxcillin; Fenoxypen; Isocillin; Ispenoral; Kavepenin; L.P.V.; Ledercillin Vk; Len V.K.; Megacilina Oral; Megacillin Oral; Microcillin-VK; Micropen-VK; Milcopen; Monocillin-E; Nadopen-V; Newcillin; Novo-VK; Novopen; Novopen-VK; Oracillin VK; Orvek; Ospen; Ospen 250; Ospen-KV; PVK; P.V.O.; Pen-V; Pen V; Pen-Vee K; Pen Vee K; Penadur-VK Mega; Penicillin-Vk; Penivoral; Penoral; Penoxilin; Pentabs; Pentacillin; Pentid; Pentranex; Pen-Vi-K; Penvisil; Pfizerpen-Vk; Primcillin; Rafapen V-K; Robicillin VK; Rocilin; Roscopenin; Servipen-V; Stabilin V-K; Suspen; Trepopen; Trepopen VK; Uticillin Vk; V-Cil-K; V-Cillin K; V-Kal-K; V-Pen; V-Penicillin Kalium; Vamosyn; Veetids; Vepicombin
(Foreign Brand names outside U.S. in italics)

FOREIGN BRAND AVAILABILITY:
Abbocillin VK (Australia)
Anapenil (Mexico)
Apo-Pen-VK (Canada)
Arcasin (Germany)
Beapen (Malaysia)
Cilacil (Argentina)
Cilicaine VK (Australia)
Cliacil (Argentina)
Compocillin VK (New-Zealand)
Crystapen V (India)
Distaquaine V-K (England)
DuraPenicillin (Germany)
Fenocin (Indonesia; Thailand)
Fenoxcillin (Denmark)
Fenoxypen (Norway; Sweden)
Isocillin (Germany)
L.P.V. (Australia)
Len V.K. (South-Africa)
Megacilina Oral (Peru)
Megacillin Oral (Germany)
Milcopen (Finland)
Nadopen-V (Canada)
Newcillin (Japan)
Novo-VK (South-Africa)
Novopen-VK (Canada)
Oracillin VK (South-Africa)
Orvek (Bahrain; Cyprus; Egypt; Iran; Iraq; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic-of-Yemen; Saudi-Arabia; Syria; United-Arab-Emirates)
Ospen (France; Malaysia)
Ospen 250 (Austria)
PVK (Australia)
Pen V (Hong-Kong)
Pen Vee K (Colombia)
Penivoral (India)
Penoral (Argentina)
Pentacillin (Philippines)
Pentid (Argentina)
Pentranex (Philippines)
Pen-Vi-K (Mexico)
Primcillin (Denmark)
Rafapen V-K (Israel)
Rocilin (Denmark)
Servipen-V (Thailand)
Trepopen VK (Philippines)
V-Cil-K (Bahamas; Bahrain; Barbados; Belize; Benin; Bermuda; Burkina-Faso; Curacao; Cyprus; Egypt; Ethiopia; Gambia; Ghana; Guinea; Guyana; Iran; Iraq; Ireland; Ivory-Coast; Jamaica; Jordan; Kenya; Kuwait; Lebanon; Liberia; Libya; Malawi; Mali; Mauritania; Mauritius; Morocco; Netherland-Antilles; Niger; Nigeria; Oman; Qatar; Republic-of-Yemen; Saudi-Arabia; Senegal; Seychelles; Sierra-Leone; South-Africa; Sudan; Surinam; Syria; Tanzania; Trinidad; Tunia; Uganda; United-Arab-Emirates; Zambia; Zimbabwe)
V-Kal-K (Japan)
V-Pen (Israel)
V-Penicillin Kalium (Japan)
Vamosyn (Philippines)
Vepicombin (Denmark)

COST OF THERAPY: $6.00 (Pharyngitis; Generic Tablet (Par); 500 mg; 4/day; 10 days)