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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (P's) » Pneumococcal Vaccine Polyvalent


PNEUMOVAX* 23 (Pneumococcal Vaccine Polyvalent), is a sterile, liquid vaccine for intramuscular or subcutaneous injection. It consists of a mixture of highly purified capsular polysaccharides from the 23 most prevalent or invasive pneumococcal types of Streptococcus pneumoniae, including the six serotypes that most frequently cause invasive drug- resistant pneumococcal infections among children and adults in the United States. 1 (See Table 1.) The 23- valent vaccine accounts for at least 90% of pneumococcal blood isolates and at least 85% of all pneumococcal isolates from sites which are generally sterile as determined by ongoing surveillance of U. S. data. 2

PNEUMOVAX 23 is manufactured according to methods developed by the MERCK Research Laboratories. Each 0.5 mL dose of vaccine contains 25 g of each polysaccharide type dissolved in isotonic saline solution containing 0.25% phenol as a preservative.

Table 1

23 Pneumococcal Capsular Types Included in PNEUMOVAX 23

Pneumococcal Types
Danish 1 2 3 4 5 6B** 7F 8 9N 9V** 10A 11A 12F 14** 15B 17F 18C 19F** 19A** 20 22F 23F** 33F
serotypes most frequently cause drug-resistant pneumococcal infections1

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