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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (B's) » Benazepril



WARNING

Use in Pregnancy: When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, benazepril HCl should be discontinued as soon as possible. See WARNINGS, Fetal/Neonatal Morbidity and Mortality.


DESCRIPTION

Benazepril HCl is a white to off-white crystalline powder, soluble (>100 mg/ml) in water, in ethanol, and in methanol. Benazepril's chemical name is 3-[[1-(ethoxy-carbonyl)-3-phenyl-(1S)-propyl]amino]-2, 3, 4, 5-tetrahydro-2-oxo-1H-1-(3S)-benzazepine-1-acetic acid monohydrochloride. Its empirical formula is C24H28N2O5·HCl, and its molecular weight is 460.96.

Benazeprilat, the active metabolite of benazepril, is a non-sulfhydryl Angiotensin-converting enzyme inhibitor. Benazepril is converted to Benazeprilat by hepatic cleavage of the ester group.

Lotensin is supplied as tablets containing 5 mg, 10 mg, 20 mg, and 40 mg of benazepril for oral administration. The inactive ingredients are cellulose compounds, colloidal silicon dioxide, crospovidone, hydrogenated castor oil (5 mg, 10 mg, and 20 mg tablets), iron oxides, lactose, magnesium stearate (40 mg tablets), polysorbate 80, propylene glycol (5 mg and 40 mg tablets), starch, talc, and titanium dioxide.

CATEGORIES, BRAND NAMES

CATEGORIES: Hypertension, essential; Pregnancy Category D; FDA Class 1C ("Little or No Therapeutic Advantage"); FDA Approved 1991 Jun; Top 200 Drugs

FDA Drug Classes: Ace Inhibitors; Antihypertensives

BRAND NAMES:

BRAND NAMES: Cibace; Cibacen; Cibacen Cor; Cibacene; Lotensin
(Foreign Brand names outside U.S. in italics)

FOREIGN BRAND AVAILABILITY:
Cibace (South-Africa)
Cibacen (Austria; Bahamas; Bahrain; Barbados; Belize; Benin; Bermuda; Burkina-Faso; Curacao; Cyprus; Denmark; Egypt; Ethiopia; Finland; Gambia; Germany; Ghana; Greece; Guinea; Guyana; Indonesia; Iran; Iraq; Israel; Israel; Italy; Ivory-Coast; Jamaica; Japan; Jordan; Kenya; Korea; Kuwait; Lebanon; Liberia; Libya; Malawi; Mali; Mauritania; Mauritius; Morocco; Netherland-Antilles; Netherlands; New-Zealand; Niger; Nigeria; Oman; Philippines; Portugal; Puerto-Rico; Qatar; Republic-Of-Yemen; Saudi-Arabia; Senegal; Seychelles; Sierra-Leone; South-Africa; Spain; Sudan; Surinam; Sweden; Switzerland; Syria; Taiwan; Tanzania; Trinidad; Tunia; Uganda; United-Arab-Emirates; Zambia; Zimbabwe)
Cibacen Cor (Germany)
Cibacene (France)

COST OF THERAPY: $317.55 (Hypertension; Lotensin Tablet; 10 mg; 1/day; 365 days)





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