XELODA® (capecitabine) tablets
XELODA (capecitabine) is a fluoropyrimidine carbamate with antineoplastic
activity. It is an orally administered systemic prodrug of 5'-deoxy-5-fluorouridine
(5'-DFUR) which is converted to 5-fluorouracil.
The chemical name for capecitabine is 5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-cytidine
and has a molecular weight of 359.35.
Capecitabine is a white to off-white crystalline powder with an aqueous
solubility of 26 mg/mL at 20 C.
XELODA is supplied as biconvex, oblong, film-coated tablets for oral
administration. Each light peach-colored tablet contains 150 mg capecitabine
and each peach-colored tablet contains 500 mg capecitabine.
The inactive ingredients in XELODA include: anhydrous lactose, croscarmellose
sodium, hydroxypropyl methylcellulose, microcrystalline cellulose, magnesium
stearate and purified water. The peach or light peach film coating contains
hydroxypropyl methylcellulose, talc, titanium dioxide, and synthetic yellow
and red iron oxides.