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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (D's) » Diphenoxylate & Atropine



DESCRIPTION

Each diphenoxylate HCl and atropine sulfate tablet contains:

Diphenoxylate Hydrochloride ................................................. 2. 5 mg

Atropine Sulfate ................................................................. 0. 025 mg

Diphenoxylate hydrochloride, an antidiarrheal, is ethyl 1-(3-cyano-3,3diphenylpropyl)-4-phenylisonipecotate monohydrochloride.

Atropine sulfate an anticholinergic, is endo-(±)-a( hydroxymethyl) benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1] oct-3-yl ester sulfate (2:1) (salt) monohydrate.

Inactive ingredients include lactose (monohydrate), magnesium stearate, microcrystalline cellulose, and pregelatinized starch (corn).

IMPORTANT INFORMATION

Diphenoxylate HCl and atropine sulfate is classified as a Schedule V controlled substance by federal law. Diphenoxylate hydrochloride is chemically related to the narcotic meperidine. Therefore, in case of overdosage, treatment is similar to that for meperidine or morphine intoxication, in which prolonged and careful monitoring is essential. Respiratory depression may be evidenced as late as 30 hours after ingestion and may recur in spite of an initial response to narcotic antagonists. A subtherapeutic amount of atropine sulfate is present to discourage deliberate overdosage.

DIPHENOXYLATE HCI AND ATROPINE SULFATE IS NOT AN INNOCUOUS DRUG AND DOSAGE RECOMMENDATIONS SHOULD BE STRICTLY ADHERED TO, ESPECIALLY IN CHILDREN. KEEP THIS AND ALL MEDICATIONS OUT OF REACH OF CHILDREN.





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