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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (i's) » Influenza Virus Vaccine


Fluzone ® , Influenza Virus Vaccine USP (Zonal Purified, Whole Virion) for intramuscular use, is a sterile suspension prepared from influenza viruses propagated in chicken embryos. The virus-containing fluids are harvested and inactivated with formaldehyde. Influenza virus is concentrated and purified in a linear sucrose density gradient solution using a continuous flow centrifuge. The virus is then further purified by chemical means and suspended in sodium phosphate-buffered isotonic sodium chloride solution. Fluzone has been standardized according to USPHS requirements for the 1998-99 influenza season and is formulated to contain 45 micrograms (µg) hemagglutinin (HA) per 0.5 mL dose, in the recommended ratio of 15 µg HA each, representative of the following three prototype strains: A/Beijing/ 262/ 95 (H1N1), A/Sydney/05/ 97 (H3N2) and B/Harbin/07/94 (a B/Beijing/184/93-like strain). 1 Thimerosal (mercury derivative) 1:10,000 is added as a preservative. Fluzone, after shaking vial well, is essentially clear and slightly opalescent in color.


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