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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (i's) » Insulin Lispro (Human Analog)


Humalog (insulin lispro, rDNA origin) is a human insulin analog that is a rapid-acting, parenteral blood glucose-lowering agent. Chemically, it is Lys(B28), Pro(B29) human insulin analog, created when the amino acids at positions 28 and 29 on the insulin B-chain are reversed. Humalog is synthesized in a special non-pathogenic laboratory strain of Escherichia coli bacteria that has been genetically altered by the addition of the gene for insulin lispro.

Humalog has the empirical formula C257H383N65O77S6 and a molecular weight of 5808, both identical to that of human insulin.

The vials and cartridges contain a sterile solution of Humalog for use as an injection. Humalog injection consists of zinc-insulin lispro crystals dissolved in a clear aqueous fluid.

Each milliliter of Humalog injection contains insulin lispro 100 Units, 16 mg glycerin, 1.88 mg dibasic sodium phosphate, 3.15 mg m-cresol, zinc oxide content adjusted to provide 0.0197 mg zinc ion, trace amounts of phenol, and water for injection. Insulin lispro has a pH of 7.0-7.8. Hycrochloric acid 10% and/or sodium hydroxide 10% may be added to adjust pH.


CATEGORIES: Diabetes Mellitus; FDA Approved 1996 Jun; Pregnancy Category B

BRAND NAMES: Humalog; Humalog Lispro; Insuline Lispro Humalog
(Foreign brand names outside U.S. in italics)

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