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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (i's) » Interferon beta-1a


AVONEX® (Interferon beta-1a) is produced by recombinant DNA technology. Interferon beta-1a is a 166 amino acid glycoprotein with a predicted molecular weight of approximately 22,500 daltons. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence of AVONEX® is identical to that of natural human interferon beta.

Using the World Health Organization (WHO) natural interferon beta standard, Second International Standard for Interferon, Human Fibroblast (Gb-23-902-531), AVONEX® has a specific activity of approximately 200 million international units (IU) of antiviral activity per mg; 30 mcg of AVONEX® contains 6 million IU of antiviral activity. The activity against other standards is not known.

AVONEX® is formulated as a sterile, white to off-white lyophilized powder for intramuscular injection after reconstitution with supplied diluent or Sterile Water for Injection, USP, preservative-free.

Each 1.0 mL (1.0 cc) of reconstituted AVONEX® contains 30 mcg of Interferon beta-1a, 15 mg Albumin Human, USP, 5.8 mg Sodium Chloride, USP, 5.7 mg Dibasic Sodium Phosphate, USP and 1.2 mg Monobasic Sodium Phosphate, USP at a pH of approximately 7.3.

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