About UsContact UsFAQsView Our NewsletterHiringTrack OrderView Cart MY ACCOUNT Ph no: (609) 848-8890
Shop with Confidence
Yahoo Shopping 5 Star- Top service Site
Email this page to your friends
Subscribe to our Newsletter!

Translate This Page:


Mastercard Visa Discover JCB


Go Daddy $1.99 Domains
You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (K's) » Ketorolac



DESCRIPTION

WARNING

Ketorolac tromethamine, a nonsteroidal anti-inflammatory drug (NSAID) is indicated for the short-term (up to 5 days) management of moderately severe, acute pain, that requires analgesia at the opioid level. It is NOT indicated for minor or chronic painful conditions. Ketorolac tromethamine is a potent NSAID analgesic, and its administration carries many risks. The resulting NSAID-related adverse events can be serious in certain patients for whom ketorolac tromethamine is indicated, especially when the drug is used inappropriately. Increasing the dose of ketorolac tromethamine beyond the label recommendations will not provide better efficacy but will result in increasing the risk of developing serious adverse events.

Gastrointestinal Effects: Ketorolac tromethamine can cause peptic ulcers, gastrointestinal bleeding, and/or perforation. Therefore, ketorolac tromethamine is CONTRAINDICATED in patients with active peptic ulcer disease, in patients with active peptic ulcer disease, in patients with recent gastrointestinal bleeding or perforation, and in patients with a history of peptic ulcer disease or gastrointestinal bleeding.

Renal Effects: Ketorolac tromethamine is CONTRAINDICATED in patients with advanced renal impairment and in patients at risk for renal failure due to volume depletion (see WARNINGS).

Risk of Bleeding: Ketorolac tromethamine inhibits platelet function and is, therefore, CONTRAINDICATED in patients with suspected or confirmed cerebrovascular bleeding, patients with hemorrhagic diathesis, incomplete hemostasis, and those at high risk of bleeding (see WARNINGS and PRECAUTIONS).

Ketorolac tromethamine is CONTRAINDICATED as prophylactic analgesic before any major surgery, and it is CONTRAINDICATED intra-operatively when hemostasis is critical because of the increased risk of bleeding.

Hypersensitivity: Hypersensitivity reactions, ranging from bronchospasm to anaphyl- actic shock, have occurred and appropriate counteractive measures must be available when administering the first dose of ketorolac tromethamine IV/IM (see CONTRAINDICATIONS and WARNINGS). Ketorolac tromethamine is CONTRAINDICATED in patients with previously demonstrated hypersensitivity to ketorolac tromethamine or allergic manifestations to aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs).

Intrathecal or Epidural Administration: Ketorolac tromethamine is CONTRAINDICATED for intrathecal or epidural administra- tion due to its alcohol content.

Labor, Delivery, and Nursing: The use of ketorolac tromethamine in labor and delivery is CONTRAINDICATED because it may adversely affect fetal circulation and inhibit uterine contractions.

The use of ketorolac tromethamine is CONTRAINDICATED in nursing mothers because of the potential adverse effects of prostaglandin-inhibiting drugs on neonates.

Concomittant Use with NSAIDs: Ketorolac tromethamine is CONTRAINDICATED in patients currently receiving ASA or N.A.D. because of the cumulative risk of inducing serious N.A.D. related side effects.

DOSAGE AND ADMINISTRATION: Oral ketorolac tromethamine is indicated only as continuation therapy to ketorolac tromethamine IV/IM, and the combined duration of use of ketorolac tromethamine IV/IM and oral ketorolac tromethamine is not to exceed 5 (five) days because of the increased risk of serious adverse events.

The recommended total daily dose of oral ketorolac tromethamine (maximum 40 mg) is significantly lower than for ketorolac tromethamine IV/IM (maximum 120 mg) (see DOSAGE AND ADMINISTRATION: Transition from Ketorolac Tromethamine IV/IM to Ketorolac Tromethamine Oral).

Special Populations: Dosage should be adjusted for patients 65 years or older, for patients under 50 kg (110 lbs) of body weight (see DOSAGE AND ADMINISTRATION), and for patients with moderately elevated serum creatinine (see WARNINGS). Doses of ketorolac tromethamine IV/IM are not to exceed 60 mg (total dose per day) in these patients.

Ketorolac tromethamine is a member of the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drugs (NSAIDs). The chemical name for ketorolac tromethamine is (±)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, 2-amino-2-(hydroxymethyl)-1,3-propanediol.

Toradol is a racemic mixture of [-]S and [+]R ketorolac tromethamine. Ketorolac tromethamine may exist in three crystal forms. All forms are equally soluble in water. Ketorolac tromethamine has a pKa of 3.5 and an n-octanol/water partition coefficient of 0.26. The molecular weight of ketorolac tromethamine is 376.41.

Toradol is available for intravenous (IV) or intramuscular (IM) administration as: 15 mg in 1 ml (1.5%), and 30 mg in 1 ml (3%) in sterile solution; 60 mg in 2 ml (3%) of ketorolac tromethamine in sterile solution is available for IM administration only. The solutions contain 10% (w/v) alcohol, USP, and 6.68 mg, 4.35 mg, and 8.70 mg, respectively, of sodium chloride in sterile water. The pH is adjusted with sodium hydroxide or hydrochloric acid and the solutions are packaged with nitrogen. The sterile solutions are clear and slightly yellow in color.

Toradol oral is available as round, white, film-coated, red-printed tablets. Each tablet contains 10 mg ketorolac tromethamine, the active ingredient, with added lactose, magnesium stearate, and microcrystalline cellulose. The white film-coating contains hydroxypropyl methylcellulose, polyethylene glycol, and titanium dioxide.

The tablets are printed with red ink which includes FD&C Red #40 Aluminum lake as the colorant. There is a large T printed on both sides of the tablet, as well as the word Toradol on one side, and the word SYNTEX on the other.

Ophthalmic Solution: Acular (ketorolac tromethamine) is a member of the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drugs (NSAIDs). The chemical name for ketorolac tromethamine is (±)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1).

Acular (ketorolac tromethamine) is supplied as a sterile isotonic aqueous 0.5% solution, with a pH of 7.4. Acular is a racemic mixture of R-(+)- and S-(-)-ketorolac tromethamine. Ketorolac tromethamine may exist in three crystal forms. All forms are equally soluble in water. Ketorolac tromethamine has a pKa of 3.5. The white to off-white crystalline substance discolors on prolonged exposure to light. The molecular weight of ketorolac tromethamine is 376.41.

CATEGORIES, BRAND NAMES

CATEGORIES: Conjunctivitis; Pain; Pregnancy Category B; FDA Class 1B (Modest Therapeutic Advantage); FDA Approved 1989 Nov

FDA Drug Class: Analgesics, General; Analgesics-Non-Narcotic; NSAID; Ocular Anti-Infective/Anti-Inflammatory; Ophthalmics, Miscellaneous

BRAND NAMES: Acular; Dolac; Kelac; Ketanov; Ketonic; Ketowin; Nodine; Tarasyn; Topadol; Toradol; Torolac; Torvin
(Foreign brand names outside U.S. in italics)

COST OF THERAPY: $22.64 (Pain; Tablet; 10 mg; 4/day; 5 days)





Contact UsBrochure RequestShipping & ReturnsPrivacy PolicySite MapCompany InformationView Shopping Cart
eGeneralMedical.com™ and the contents of this site are Trademark and Copyright protected – All rights reserved 2000-2010.
Ordering Help
Shipping & Returns Help
Partner With Us
Our Policies
Contact the Webmaster with any questions regarding the content of this website.

eGeneralMedical.com - Health Care Supplies, Medical Equipment, Alternative Health,Stethoscopes, Blood Pressure Monitors, Scales/Body Fat Monitors, Diabetic Supplies, Air Purifiers, White Noise Machines, Vitamins, Massage/Spa., Medical PDA Software