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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (K's) » Ketorolac Tromethamine (ophthalmic solution)



DESCRIPTION

ACULAR ® PF(ketorolac tromethamine ophthalmic solution) Preservative-Free is a member of the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drugs (NSAIDs) for ophthalmic use. Ketorolac tromethamines chemical name is ()-5-benzoyl-2, 3-dihydro-ill pyrrolizine-1-carboxylic acid compound with 2-amino-2-(hydroxymethyl)-1, 3-propanediol(1:1).

ACULAR ® PF is a racemic mixture of R-(+) and S-(-)-ketorolac tromethamine. Ketorolac tromethamine may exist in three crystal forms. All forms are equally soluble in water. The pKa of ketorolac is 3.5. This white to off-white crystalline substance discolors on prolonged exposure to light. The molecular weight of ketorolac tromethamine is 376.41. The osmolality of ACULAR ® PF is 290 mOsmol/kg.

Each ml of ACULAR ® PF contains: Active ingredient: ketorolac tromethamine 0.5%. Inactives: sodium chloride; hydrochloric acid and/or sodium hydroxide to adjust the pH to 7.4; and purified water.





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