About UsContact UsFAQsView Our NewsletterHiringTrack OrderView Cart MY ACCOUNT Ph no: (609) 848-8890
Shop with Confidence
Yahoo Shopping 5 Star- Top service Site
Email this page to your friends
Subscribe to our Newsletter!

Translate This Page:

Mastercard Visa Discover JCB

Go Daddy $1.99 Domains
You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (L's) » Lepirudin


REFLUDAN [lepirudin( rDNA) for injection] is a highly specific direct inhibitor of thrombin. Lepirudin (chemical designation: [Leul, Thr 2]-63-desulfohirudin) is a recombinant hirudin derived from yeast cells. The polypeptide composed of 65 amino acids has a molecular weight of 6979.5 daltons. Natural hirudin is produced in trace amounts as a family of highly homologous isopolypeptides by the leech Hirudo medicinalis. The biosynthetic molecule (lepirudin) is identical to natural hirudin except for substitution of leucine for isoleucine at the N-terminal end of the molecule and the absence of a sulfate group on the tyrosine at position 63.

The activity of lepirudin is measured in a chromogenic assay. One antithrombin unit (ATU) is the amount of lepirudin that neutralizes one unit of World Health Organization preparation 89/588 of thrombin. The specific activity of lepirudin is approximately 16,000 ATU/mg. Its mode of action is independent of antithrombin III. Platelet factor 4 does not inhibit lepirudin. One molecule of lepirudin binds to one molecule of thrombin and thereby blocks the thrombogenic activity of thrombin. As a result, all thrombin-dependent coagulation assays are affected, e.g., activated partial thromboplastin time (aPTT) values increase in a dose-dependent fashion (Roethig 1991).

REFLUDAN is supplied as a sterile, white, freeze-dried powder for injection or infusion and is freely soluble in Water for Injection USP or 0.9% Sodium Chloride Injection USP.

Each vial of REFLUDAN contains 50 mg lepirudin. Other ingredients are 40 mg mannitol and sodium hydroxide for adjustment of pH to approximately 7.

Contact UsBrochure RequestShipping & ReturnsPrivacy PolicySite MapCompany InformationView Shopping Cart
eGeneralMedical.com™ and the contents of this site are Trademark and Copyright protected – All rights reserved 2000-2010.
Ordering Help
Shipping & Returns Help
Partner With Us
Our Policies
Contact the Webmaster with any questions regarding the content of this website.

eGeneralMedical.com - Health Care Supplies, Medical Equipment, Alternative Health,Stethoscopes, Blood Pressure Monitors, Scales/Body Fat Monitors, Diabetic Supplies, Air Purifiers, White Noise Machines, Vitamins, Massage/Spa., Medical PDA Software