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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (L's) » Loracarbef



DESCRIPTION

Loracarbef is a synthetic b-lactam antibiotic of the carbacephem class for oral administration. Chemically, carbacephems differ from cephalosporin-class antibiotics in the dihydrothiazine ring where a methylene group has been substituted for a sulfur atom.

The chemical name for loracarbef is: (6R,7S)-7-[(R)-2-amino-2-phenylacetamido]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2- carboxylic acid, monohydrate.

It is a white to off-white solid with a molecular weight of 367.8. The empirical formula is C16H16ClN3O4H2O.

Lorabid Pulvules and Lorabid for Oral Suspension are intended for oral administration only.

Each Pulvule contains loracarbef equivalent to 200 mg (0.57 mmol) or 400 mg (1.14 mmol) anhydrous loracarbef activity. They also contain cornstarch, dimethicone, F Dy & C blue No. 2, gelatin, iron oxides, magnesium stearate, titanium dioxide, and other inactive ingredients.

After reconstitution, each 5 ml of Lorabid for Oral Suspension contains loracarbef equivalent to 100 mg (0.286 mmol) or 200 mg (0.57 mmol) anhydrous loracarbef activity. The suspensions also contain cellulose, F Dy & C red No. 40, flavors, methylparaben, propylparaben, simethicone emulsion, sodium carboxymethylcellulose, sucrose, and xanthan gum.

CATEGORIES, BRAND NAMES

CATEGORIES: Bronchitis, acute; Bronchitis, chronic, acute exacerbation; Cystitis; Infection, ear, middle; Infection, lower respiratory tract; Infection, sinus; Infection, skin and skin structures; Infection, upper respiratory tract; Infection, urinary tract; Pharyngitis; Pneumonia; Pyelonephritis; Tonsillitis; FDA Class 1C ("Little or No Therapeutic Advantage"); Pregnancy Category B; FDA Approved 1991 Dec; Top 200 Drugs

FDA Drug Classes: Antibacterials, Miscellaneous; Cephalosporins

BRAND NAMES:

BRAND NAMES: Carbac; Lorabid; Lorafem; Lorbef
(Foreign Brand names outside U.S. in italics)

FOREIGN BRAND AVAILABILITY:
Carbac (Mexico)
Lorafem (Germany)
Lorbef (Colombia)

COST OF THERAPY: 176.12 (Respiratory Infections; Capsule; 200 mg; 4/day; 14 days)





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