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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (L's) » Loratadine and Pseudoephedrine



DESCRIPTION

Claritin-D 12 Hour Extended Release Tablets: Claritin-D 12 hour extended release tablets contain 5 mg loratadine in the tablet coating for immediate release and 120 mg pseudoephedrine sulfate equally distributed between the tablet coating for immediate release and the barrier-coated extended release core.

The inactive ingredients are acacia, butylparaben, calcium sulfate, carnauba wax, corn starch, lactose, magnesium stearate, microcrystalline cellulose, neutral soap, oleic acid, povidone, rosin, sugar, talc, titanium dioxide, white wax, and zein.

Claritin-D 24 Hour Extended Release Tablets: Claritin-D 24 hour extended release tablets contain 10 mg loratadine in the tablet film coating for immediate release and 240 mg pseudoephedrine sulfate in the tablet core which is released slowly allowing for once-daily administration.

The inactive ingredients for oval, biconvex Claritin-D 24 hour extended release tablets are calcium phosphate, carnauba wax, ethylcellulose, hydroxypropyl methylcellulose, magnesium stearate, polyethylene glycol, povidone, silicon dioxide, sugar, titanium dioxide, and white wax.

Loratadine is a long-acting antihistamine having the empirical formula C22H23ClN2O2; the chemical name ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate.

The molecular weight of loratadine is 382.89. It is a white to off-white powder, not soluble in water, but very soluble in acetone, alcohol, and chloroform.

Pseudoephedrine sulfate is the synthetic salt of one of the naturally occurring dextrorotatory diastereomers of ephedrine and is classified as an indirect sympathomimetic amine. The empirical formula for pseudoephedrine sulfate is (C10H15NO)2H2SO4; the chemical name is a-[1-(methyl-amino) ethyl]-[S-(R*,R*)]-benzenemethanol sulfate (2:1)(salt).

The molecular weight of pseudoephedrine sulfate is 428.54. It is a white powder, freely soluble in water and methanol and sparingly soluble in chloroform.

CATEGORIES, BRAND NAMES

CATEGORIES: Rhinitis, seasonal allergic; Pregnancy Category B; FDA Class 4S ("Standard Review"); FDA Approved 1994 Nov; Top 200 Drugs

FDA Drug Classes: Antihistamines; Cold Remedies

BRAND NAMES:

BRAND NAMES: Airet; Bonalerg - D; Chlor-Tripolon N.D.; Claratyne Cold; Claratyne Decongestant; Clarinase; Claritin-D; Clarityne-D; Clarityne D Repetabs; Claritin Extra; Lertamine - D; Loratyne D; Polaratyne - D; Rhinase; Rinomex; Sinhistan D; Talorat D
(Foreign Brand names outside U.S. in italics)

FOREIGN BRAND AVAILABILITY:
Airet (Colombia)
Bonalerg - D (Guatemala)
Chlor-Tripolon N.D. (Canada)
Claratyne Cold (New-Zealand)
Claratyne Decongestant (New-Zealand)
Clarinase (Bahrain; Costa-Rica; Cyprus; Dominican-Republic; Egypt; El-Salvador; Guatemala; Honduras; Hong-Kong; Indonesia; Iran; Iraq; Israel; Jordan; Korea; Kuwait; Lebanon; Libya; Malaysia; Nicaragua; Oman; Panama; Philippines; Qatar; Republic-of-Yemen; Saudi-Arabia; Syria; Taiwan; Thailand; United-Arab-Emirates)
Clarityne-D (Greece)
Clarityne D Repetabs (Colombia; Ecuador; Mexico; Peru)
Claritin Extra (Canada)
Lertamine - D (Mexico)
Loratyne D (South-Africa)
Polaratyne - D (South-Africa)
Rhinase (Philippines)
Rinomex (Peru)
Sinhistan D (Costa-Rica; Dominican-Republic; El-Salvador; Guatemala; Honduras; Nicaragua; Panama)
Talorat D (Costa-Rica; Dominican-Republic; El-Salvador; Guatemala; Honduras; Nicaragua; Panama)

COST OF THERAPY: $75.60 (Rhinitis; Claritin-D Tablet Extended Release; 5 mg;120 mg; 2/day; 30 days)





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