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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (L's) » Losartan



Use In Pregnancy: When used in pregnancy during the second and third trimesters, drugs that act directly on the renin-angiotensin system can case injury and even death to the developing fetus. When pregnancy is detected, losartan potassium should be discontinued as soon as possible. See WARNINGS, Fetal/Neonatal/Morbidity and Mortality.

Losartan potassium, the first of a new class of antihypertensives, is an angiotensin II receptor (type AT1) antagonist.

Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1[p-(o-1H-tetrazol-5- ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Its empirical formula is C22H22ClKN6O.

Losartan potassium is a white to off-white free flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Cozaar is available for oral administration containing either 25 mg or 50 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hydroxypropyl methylcellulose, titanium dioxide, D&C yellow No. 10 aluminum lake and FD&C blue No. 2 aluminum lake.

Cozaar 25 mg and 50 mg contain potassium in the following amounts: 2.12 mg (0.054 mEq) and 4.24 mg (0.108 mEq) respectively.


CATEGORIES: Hypertension, essential; FDA Class 1S ("Standard Review"); FDA Approved 1995 Apr; Pregnancy Category C; Top 200 Drugs

FDA Drug Classes: Antihypertensives


BRAND NAMES: Cozaar; Lorzaar; Losacar; Ocsaar
(Foreign Brand names outside U.S. in italics)

Lorzaar (Germany)
Losacar (India)
Ocsaar (Israel)

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