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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (M's) » Measles, Mumps, and Rubella Virus Vaccine Live



DESCRIPTION

M-M-R* II (Measles, Mumps, and Rubella Virus Vaccine Live) is a live virus vaccine for immunization against measles (rubeola), mumps and rubella (German measles).

M-M-R II is a sterile lyophilized preparation of (1) ATTENUVAX* (Measles Virus Vaccine Live), a more attenuated line of measles virus, derived from Enders attenuated Edmonston strain and grown in cell cultures of chick embryo; (2) MUMPSVAX* (Mumps Virus Vaccine Live), the Jeryl Lynn (B level) strain of mumps virus grown in cell cultures of chick embryo; and (3) MERUVAX* II (Rubella Virus Vaccine Live), the Wistar RA 27/3 strain of live attenuated rubella virus grown in human diploid cell (WI-38) culture. 12 The vaccine viruses are the same as those used in the manufacture of ATTENUVAX (Measles Virus Vaccine Live), MUMPSVAX (Mumps Virus Vaccine Live) and MERUVAX II (Rubella Virus Vaccine Live). The three viruses are mixed before being lyophilized. The product contains no preservative.

The reconstituted vaccine is for subcutaneous administration. When reconstituted as directed, the dose for injection is 0.5 mL and contains not less than the equivalent of 1,000 TCID50 (tissue culture infectious doses) of the U. S. Reference Measles Virus; 20,000 TCID50 of the U. S. Reference Mumps Virus; and 1,000 TCID50 of the U. S. Reference Rubella Virus. Each dose contains approximately 25 mcg of neomycin. The product contains no preservative. Sorbitol and hydrolized gelatin are added as stabilizers.





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