M-M-R* II (Measles, Mumps, and Rubella Virus Vaccine Live) is a live
virus vaccine for immunization against measles (rubeola), mumps and rubella
M-M-R II is a sterile lyophilized preparation of (1) ATTENUVAX* (Measles
Virus Vaccine Live), a more attenuated line of measles virus, derived
from Enders attenuated Edmonston strain and grown in cell cultures of
chick embryo; (2) MUMPSVAX* (Mumps Virus Vaccine Live), the Jeryl Lynn
(B level) strain of mumps virus grown in cell cultures of chick embryo;
and (3) MERUVAX* II (Rubella Virus Vaccine Live), the Wistar RA 27/3 strain
of live attenuated rubella virus grown in human diploid cell (WI-38) culture.
12 The vaccine viruses are the same as those used in the manufacture of
ATTENUVAX (Measles Virus Vaccine Live), MUMPSVAX (Mumps Virus Vaccine
Live) and MERUVAX II (Rubella Virus Vaccine Live). The three viruses are
mixed before being lyophilized. The product contains no preservative.
The reconstituted vaccine is for subcutaneous administration. When reconstituted
as directed, the dose for injection is 0.5 mL and contains not less than
the equivalent of 1,000 TCID50 (tissue culture infectious doses) of the
U. S. Reference Measles Virus; 20,000 TCID50 of the U. S. Reference Mumps
Virus; and 1,000 TCID50 of the U. S. Reference Rubella Virus. Each dose
contains approximately 25 mcg of neomycin. The product contains no preservative.
Sorbitol and hydrolized gelatin are added as stabilizers.