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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (M's) » Meperidine


Meperidine hydrochloride is ethyl 1-methyl-4-phenylisonipecotate hydrochloride, a white crystalline substance with a melting point of 186°C to 189°C. It is readily soluble in water and has a neutral reaction and a slightly bitter taste. The solution is not decomposed by a short period of boiling.

The syrup is a pleasant-tasting, nonalcoholic, banana-flavored solution containing 50 mg of meperidine hydrochloride, per 5 ml teaspoon (25 drops contain 13 mg of meperidine hydrochloride). The tablets contain 50 mg or 100 mg of the analgesic.

Meperidine hydrochloride injectable is supplied in Carpuject with InterLink and Carpuject Sterile Cartridge-Needle Units, SmartPak Injection Delivery System of 2.5% (25 mg/1 ml), 5% (50 mg/1 ml), 7.5% (75 mg/1 ml), and 10% (100 mg/1 ml). Uni-Amp Unit Dose Pak--ampuls of 5% solution (25 mg/0.5 ml), (50 mg/1 ml), (75 mg/1.5 ml), (100 mg/2 ml), and 10% solution (100 mg/1 ml). Uni-Nest Pak--ampuls of 5% solution (25 mg/0.5 ml), (50 mg/1 ml), (75 mg/1.5), (100 mg/2 ml), and 10% solution (100 mg/1 ml). Multiple-dose vials of 5% and 10% solutions contain metacresol 0.1% as preservative.

The pH of meperidine solutions is adjusted between 3.5 and 6 with sodium hydroxide or hydrochloric acid.

Meperidine hydrochloride, brand of meperidine hydrochloride, 5 percent solution has a specific gravity of 1.0086 at 20°C and 10 percent solution, a specific gravity of 1.0165 at 20°C.

Inactive Ingredients Tablets: Calcium Sulfate, Dibasic Calcium phosphate, Starch, Stearic Acid, Talc. Syrup: Benzoic Acid, Flavor, Liquid Glucose, Purified Water, Saccharin Sodium.


CATEGORIES: Pain; DEA Class C.I. FDA Approved 1942 Nov; WHO Formulary

FDA Drug Class: Analgesics, General; Analgesics-Narcotic; Anesthesia, Adjuncts To/Analeptics; Anesthetics, General

BRAND NAMES: Alodan "Gerot"; Centralgin; Demerol; Dolantin; Dolantina; Dolantine; Dolestine; Doloneurin; Dolosal; Neomochin; Opistan; Pethidine; Pethidine Injection; Pethidine Roche; Pethidine Tablet; Petidin
(Foreign brand names outside U.S. in italics)

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