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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (M's) » Methotrexate



DESCRIPTION

Methotrexate (formerly Amethopterin) is an antimetabolite used in the treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis. 

Chemically methotrexate is N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid.

Molecular weight: 454.45 C20H22N8O5 

Methotrexate Sodium Tablets for oral administration are available in bottles of 100 and in a packaging system designated as the RHEUMATREX®Methotrexate Sodium Dose Pack for therapy with a weekly dosing schedule of 5 mg, 7.5 mg, 10 mg, 12.5 mg and 15 mg. Methotrexate Sodium Tablets contain an amount of methotrexate sodium equivalent to 2.5 mg of methotrexate and the following inactive ingredients: Lactose, Magnesium Stearate and Pregelatinized Starch. May also contain Corn Starch. 

Methotrexate Sodium Injection and for Injection products are sterile and non-pyrogenic and may be given by the intramuscular, intravenous, intra-arterial or intrathecal route. (See DOSAGE AND ADMINISTRATION.) However, the preservative formulation contains Benzyl Alcohol and must not be used for intrathecal or high dose therapy. 

Methotrexate Sodium Injection, Isotonic Liquid, Preservative Protected is available in 25 mg/mL, 2 mL (50 mg) and 10 mL (250 mg) vials. 

Each 25 mg/mL, 2 mL and 10 mL vial contains methotrexate sodium equivalent to 50 mg and 250 mg methotrexate respectively, 0.90% w/v of Benzyl Alcohol as a preservative, and the following inactive ingredients: Sodium Chloride 0.260% w/v and Water for Injection qs ad 100% v. Sodium Hydroxide and, if necessary, Hydrochloric Acid are added to adjust the pH to approximately 8.5. 

Methotrexate LPF®Sodium (methotrexate sodium injection), Isotonic Liquid, Preservative Free, for single use only, is available in 25 mg/mL, 2 mL (50 mg), 4 mL (100 mg), 8 mL (200 mg) and 10 mL (250 mg) vials. 

Each 25 mg/mL, 2 mL, 4 mL, 8 mL and 10 mL vial contains methotrexate sodium equivalent to 50 mg, 100 mg, 200 mg and 250 mg methotrexate respectively, and the following inactive ingredients: Sodium Chloride 0.490% w/v and Water for Injection qs ad 100% v. Sodium Hydroxide and if necessary, Hydrochloric Acid are added to adjust the pH to approximately 8.5. The 2 mL, 4 mL, 8 mL and 10 mL solutions contain approximately 0.43 mEq, 0.86 mEq, 1.72 mEq and 2.15 mEq of Sodium per vial, respectively, and are isotonic solutions. 

Methotrexate Sodium for Injection, Lyophilized, Preservative Free, for single use only, is available in 20 mg and 1 gram vials. 

Each 20 mg and 1 g vial of lyophilized powder contains methotrexate sodium equivalent to 20 mg and 1 g methotrexate respectively. Contains no preservative. Sodium Hydroxide and if necessary, Hydrochloric Acid are added during manufacture to adjust the pH. The 20 mg vial contains approximately 0.14 mEq of Sodium; and the 1 g vial contains approximately 7 mEq Sodium. 





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