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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (M's) » Metoprolol Succinate


Toprol-XL, metoprolol succinate, is a beta1-selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended release tablets. Toprol-XL has been formulated to provide a controlled and predictable release of metoprolol for once daily administration. The tablets comprise a multiple unit system containing metoprolol succinate in a multitude of controlled release pellets. Each pellet acts as a separate drug delivery unit and is designed to deliver metoprolol continuously over the dosage interval. The tablets contain 47.5 mg, 95 mg and 190 mg of metoprolol succinate equivalent to 50, 100 and 200 mg of metoprolol tartrate, USP, respectively. Its chemical name is (±) 1-(isopropylamino)-3-[p-(2-methoxyethyl) phenoxy]-2-propanol succinate (2:1) (salt).

Metoprolol succinate is a white crystalline powder with a molecular weight of 652.8. It is freely soluble in water; soluble in methanol; sparingly soluble in ethanol; slightly soluble in dichloromethane and 2- propanol; practically insoluble in ethyl-acetate, acetone, diethylether and heptane. Inactive ingredients: silicon dioxide, cellulose compounds, sodium stearyl fumarate, polyethylene glycol, titanium dioxide, paraffin.


CATEGORIES: Angina pectoris; Hypertension, essential; Pregnancy Category C; FDA Approved 1992 Jan; Top 200 Drugs

FDA Drug Classes: Antianginals; Antihypertensives; Beta Blockers


BRAND NAMES: Beloc-Zok; Betaloc; Betaloc CR; Betaloc Zok; Betazok; Lopresor; Seloken-Zok; Selozok; Toprol Xl
(Foreign Brand names outside U.S. in italics)

Beloc-Zok (Germany)
Betaloc (New-Zealand)
Betaloc CR (New-Zealand)
Betaloc Zok (Colombia; Hong-Kong)
Betazok (Philippines)
Lopresor (Colombia)
Seloken-Zok (Mexico)
Selozok (Denmark; Indonesia)

COST OF THERAPY: $211.70 (Hypertension; Toprol Xl Tablet; 50 mg; 1/day; 365 days)

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