AGGRENOXTM is a combination antiplatelet
agent intended for oral administration.
Each hard gelatin capsule
contains 200 mg dipyridamole in
an extended-release form and
25 mg aspirin, as an immediate-release
sugar-coated tablet. In addition,
each capsule contains the
following inactive ingredients: acacia, aluminum
stearate, colloidal silicon dioxide, corn
starch, dimethicone, hydroxypropyl methylcellulose, hydroxypropyl methylcellulose
phthalate, lactose monohydrate,
methacrylic acid copolymer, microcrystalline
cellulose, povidone, stearic acid, sucrose, talc, tartaric acid, titanium
dioxide and triacetin.
Each capsule shell
contains gelatin, red iron
oxide and yellow
iron oxide, titanium dioxide
Dipyridamole is an antiplatelet
agent chemically described as
2,6-bis(diethanolamino)-4,8-dipiperidino- pyrimido(5,4-d) pyrimidine
It has the following molecular formula
C24H40N8O4 with a molecular
weight of 504.63.
Dipyridamole is an odorless yellow
having a bitter taste. It is soluble
in dilute acids, methanol
and chloroform, and is practically insoluble in water.
The antiplatelet agent
aspirin (acetylsalicylic acid)
is chemically known as benzoic acid, 2-(acetyloxy)-, and has the following
molecular formula C9H8O4
with a molecular weight
Aspirin is an odorless white
or powdery substance. When exposed to moisture, aspirin
hydrolyzes into salicylic and acetic acids, and gives off a vinegary odor.
It is highly lipid soluble
and slightly soluble in water.