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You are here: Home » Products Listed by Brand » McKesson Products » Drug Reference (A's) » Atenolol and Chlorthalidone



DESCRIPTION

Atenolol and chlorthalidone is for the treatment of hypertension. It combines the antihypertensive activity of two agents: a beta1-selective (cardioselective) hydrophilic blocking agent (atenolol) and a monosulfonamyl diuretic (chlorthalidone). Atenolol is Benzeneacetamide, 4-[2’-hydroxy-3’-[( l-methylethyl) amino] propoxyl.


Atenolol (free base) is a relatively polar hydrophilic compound with a water solubility of 26.5 mg/mL at 37° C. It is freely soluble in 1 N HCl (300 mg/mL at 25° C) and less soluble in chloroform (3 mg/mL at 25° C). Chlorthalidone is 2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl) benzene sulfonamide.

Chlorthalidone has a water solubility of 12 mg/100 mL at 20° C. Atenolol and Chlorthalidone tablets for oral administration are available as:

Atenolol . . . . . . . . . . . . . . . . . . . . . . . . 50 mg
Chlorthalidone, . . . . . . . . . . . . . . . . . . . 25 mg

Or

Atenolol . . . . . . . . . . . . . . . . . . . . . . . 100 mg
Chlorthalidone, . . . . . . . . . . . . . . . . . . . 25 mg

In addition each tablet contains: Magnesium stearate; microcrystalline cellulose; povidone; sodium starch glycolate.





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