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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (E's) » Esmolol



DESCRIPTION

BREVIBLOC® INJECTION (esmolol hydrochloride)

BREVIBLOC® (esmolol HCl) is a beta 1-selective (cardioselective) adrenergic receptor blocking agent with a very short duration of action (elimination half-life is approximately 9 minutes).

Esmolol HCl is: (±)-Methyl-p-[2-hydroxy-3-(isopropylamino)propoxy]hydrocinnamate hydrochloride

Esmolol HCl has the empirical formula C16H26NO4Cl and a molecular weight of 331.8. It has one asymmetric center and exists as an enantiomeric pair.

Esmolol HCl is a white to off-white crystalline powder. It is a relatively hydrophilic compound which is very soluble in water and freely soluble in alcohol. Its partition coefficient (octanol/water) at pH 7.0 is 0.42 compared to 17.0 for propranolol.

BREVIBLOC INJECTION is a clear, colorless to light yellow, sterile, nonpyrogenic solution.

2500 mg, 10 mL Ampul - Each mL contains 250 mg esmolol HCl in 25% Propylene Glycol, USP, 25% Alcohol, USP and Water for Injection, USP; buffered with 17.0 mg Sodium Acetate, USP, and 0.00715 mL Glacial Acetic Acid, USP. Sodium hydroxide and/or hydrochloric acid added, as necessary, to adjust pH to 3.5-5.5. 100 mg,

10 mL Single Dose Vial - Each mL contains 10 mg esmolol HCl and Water for Injection, USP; buffered with 2.8 mg Sodium Acetate, USP and 0.546 mg Glacial Acetic Acid, USP. Sodium hydroxide and/or hydrochloric acid added , as necessary to adjust pH to 4.5-5.5.





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