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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (F's) » Fexofenadine HCl and Pseudoephedrine HCl



DESCRIPTION

Allegra-D (fexofenadine HCl and pseudoephedrine HCl) Extended-Release Tablets for oral administration contain 60 mg fexofenadine HCl for immediate-release and 120 mg pseudoephedrine HCl for extended-release. Tablets also contain as excipients: microcrystalline cellulose, pregelatinized starch, croscarmellose sodium, magnesium stearate, carnauba wax, stearic acid, silicon dioxide, hydroxypropyl methylcellulose and polyethylene glycol.

Fexofenadine HCl is a histamine H1-receptor antagonist with the chemical name (±)-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-butyl]-a, a-dimethyl benzeneacetic acid hydrochloride.

The molecular weight is 538.13 and the empirical formula is C32H39NO4HCl. Fexofenadine HCl is a white to off-white crystalline powder. It is freely soluble in methanol and ethanol, slightly soluble in chloroform and water, and insoluble in hexane. Fexofenadine HCl is a racemate and exists as a zwitterion in aqueous media at physiological pH.

Pseudoephedrine HCl is an adrenergic (vasoconstrictor) agent with the chemical name [S-(R*,R*)]-a-[1-(methylamino)ethyl]-benzenemethanol HCl.

The molecular weight is 201.70. The molecular formula is C10H15NOHCl. Pseudoephedrine HCl occurs as fine, white to off-white crystals or powder, having a faint characteristic odor. It is very soluble in water, freely soluble in alcohol, and sparingly soluble in chloroform.





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