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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (F's) » Fluticasone Propionate (inhalation)



DESCRIPTION

Fluticasone propionate is a corticosteroid having the chemical name S-(fluoromethyl)6a,9-difluoro-11b, 17-dihydroxy-16a-methyl-3-oxoandrosta-1,4-diene-17b-carbothioate, 17-propionate.

Fluticasone propionate is a white to off-white powder with a molecular weight of 500.6, and the empirical formula is C25H31F3O5S. It is practically insoluble in water, freely soluble in dimethyl sulfoxide and dimethylformamide, and slightly soluble in methanol and 95% ethanol.

Inhalation Powder

Flovent Rotadisk 50 mg, 100 mg, and 250 mg contain a dry powder presentation of fluticasone propionate intended for oral inhalation only. Each double-foil Rotadisk contains four blisters. Each blister contains a mixture of 50, 100, or 250 mg of microfine fluticasone propionate blended with lactose to a total weight of 25 mg. The contents of each blister are inhaled using a specially designed plastic device for inhaling powder called the Diskhaler. After a fluticasone propionate Rotadisk is loaded into the Diskhaler, a blister containing medication is pierced and the fluticasone propionate is dispersed into the air stream created when the patient inhales through the mouthpiece.

The amount of drug delivered to the lung will depend on patient factors such as inspiratory flow. Under standardized in vitro testing, Flovent Rotadisk delivers 44, 88, or 220 mg of fluticasone propionate from Flovent Rotadisk 50 mg, 100 mg, or 250 mg, respectively, when tested at a flow rate of 60 L/min for 3 seconds. In adult and adolescent patients with asthma, mean peak inspiratory flow (PIF) through the Diskhaler was 123 L/min (range, 88 to 159 L/min), and in pediatric patients 4 to 11 years of age with asthma, mean PIF was 110 L/min (range, 43 to 175 L/min).

Inhalation Aerosol

Flovent 44 mg, 110 mg, and 220 mcg inhalation aerosol are pressurized, metered-dose aerosol units intended for oral inhalation only. Each unit contains a microcrystalline suspension of fluticasone propionate (micronized) in a mixture of two chlorofluorocarbon propellants (trichlorofluoromethane and dichlorodifluoromethane) with lecithin. Each actuation of the inhaler delivers 50, 125, or 250 mg of fluticasone propionate from the valve, and 44, 110, or 220 mg, respectively, of fluticasone propionate from the actuator.

CATEGORIES, BRAND NAMES

CATEGORIES: Dermatosis, corticosteroid-responsive; Rhinitis, perennial allergic; Rhinitis, seasonal allergic; Pregnancy Category C; FDA Class 1C ("Little or No Therapeutic Advantage"); FDA Approved 1990 Dec; Top 200 Drugs

FDA Drug Classes: Corticosteroids-Inhalation/Nasal; Topical Steroids

BRAND NAMES:

BRAND NAMES: Atemur Mite; Cutivate; Flixonase; Flixonase Nasal Spray; Flixotide; Flixotide Disk; Flixotide Disks; Flixotide Inhaler; Flonase; Flonase Aq; Flovent; Flunase; Flutide; Flutivate; Zoflut
(Foreign Brand names outside U.S. in italics)

FOREIGN BRAND AVAILABILITY:
Atemur Mite (Germany)
Flixonase (Austria; Bahamas; Barbados; Belize; Bermuda; Bulgaria; Colombia; Costa-Rica; Curacao; Czech-Republic; Denmark; Dominican-Republic; El-Salvador; England; Finland; France; Guatemala; Guyana; Honduras; Hong-Kong; Hungary; Indonesia; Israel; Italy; Jamaica; Korea; Malaysia; Mexico; Netherland-Antilles; Netherlands; Nicaragua; Panama; Peru; Puerto-Rico; Russia; Surinam; Taiwan; Thailand; Trinidad; Turkey)
Flixonase Nasal Spray (New-Zealand)
Flixotide (Austria; Bahamas; Barbados; Belize; Bermuda; Bulgaria; Curacao; Czech-Republic; Denmark; England; Finland; France; Guyana; Hong-Kong; Hungary; Indonesia; Israel; Italy; Jamaica; Korea; Mexico; Netherland-Antilles; Netherlands; Peru; Philippines; Puerto-Rico; Russia; South-Africa; Surinam; Taiwan; Thailand; Trinidad; Turkey)
Flixotide Disk (New-Zealand)
Flixotide Disks (Australia)
Flixotide Inhaler (Australia)
Flutide (Germany; Japan)
Flutivate (Germany; Norway)

COST OF THERAPY: $262.80 (Rhinitis; Flovent Aerosol; 110 mcg; 2/day; 365 days)





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