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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (G's) » Glatiramer Acetate



DESCRIPTION

COPAXONE® is the brand name for glatiramer acetate (formerly known as copolymer-1). Glatiramer acetate, the active ingredient of COPAXONE®, consists of the acetate salts of synthetic polypeptides, containing four naturally occurring amino acids: L-glutamic acid,L-alanine, L-tyrosine, and L-lysine with an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. The average molecular weight of glatiramer acetate is 4,700-11,000 daltons.

Chemically, glatiramer acetate is designated L-glutamic acid polymer with L-alanine, L-lysine and L-tyrosine, acetate(salt). Its structural formula is:

(Glu, Ala, Lys, Tyr) x.X CH3COOH

(C5H9NO4 C3H7NO2 C6H14N2O2 C9H11NO3) xx C2H4O2

CAS- 147245-92-9

COPAXONE ® is a white to off-white, sterile, lyophilized powder containing 20mg of glatiramer acetate and 40mg of manrntol. It is supplied in single-usevials for subcutaneous administration after reconstitution with the diluent supplied (Sterile Water for Injection).





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