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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (i's) » Ipratropium Bromide (intranasal)


The active ingredient in Atrovent nasal spray is ipratropium bromide monohydrate. It is an anticholinergic agent chemically described as 8-azoniabicyclo (3.2.1) octane,3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide, monohydrate (endo,syn)-, (±)- :a synthetic quaternary ammonium compound, chemically related to atropine.

Ipratropium bromide has the chemical formula C20H30BrNO3H2O and a molecular weight of 430.4.

Ipratropium bromide is a white to off-white, crystalline substance. It is freely soluble in lower alcohols and water, existing in an ionized state in aqueous solutions, and relatively insoluble in non-polar media.

Atrovent nasal spray 0.03% is a metered-dose, manual pump spray unit which delivers 21 mcg (70 mL) ipratropium bromide per spray on an anhydrous basis in an isotonic, aqueous solution with pH adjusted to 4.7. It also contains benzalkonium chloride, edetate disodium, sodium chloride, sodium hydroxide, hydrochloric acid, and purified water. Each bottle contains 345 sprays.

Atrovent nasal spray 0.06% is intended for local administration to the nasal mucosa to control rhinorrhea in patients with the common cold. It contains 0.06% ipratropium bromide on an anhydrous basis (42 mcg/spray) in an isotonic, aqueous solution with pH-adjusted to 4.7, which also contains benzalkonium cholride, edetate disodium, sodium chloride, sodium hyrdroxide, hydrochloric acid, and purified water.


CATEGORIES: Bronchitis, chronic; Emphysema; FDA Approved 1986 Dec; Pregnancy Category B; Top 200 Drugs

FDA Drug Classes: Antiasthmatics


BRAND NAMES: Aerovent; Apovent; Atem; Atronase; Atrovent; Atrovent Aerosol; Atrovent Nasal; Disne-Asmol; Ipravent; Ipvent; Narilet; Tropium
(Foreign Brand names outside U.S. in italics)

Aerovent (Bahrain; Cyprus; Egypt; Iran; Iraq; Israel; Israel; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic-Of-Yemen; Saudi-Arabia; Syria; United-Arab-Emirates)
Apovent (Israel)
Atem (Italy)
Atronase (Belgium)
Atrovent Aerosol (Australia; New-Zealand; New-Zealand)
Atrovent Nasal (Australia; Hong-Kong; New-Zealand; New-Zealand)
Ipravent (India)
Ipvent (South-Africa)
Narilet (Spain)
Tropium (Costa-Rica; Dominican-Republic; El-Salvador; Guatemala; Honduras; Nicaragua; Panama)

HCFA JCODE(S): J7645 per ml INH

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