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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (i's) » Isoflurane


Isoflurane, USP, a nonflammable liquid administered by vaporizing, is a general inhalation anesthetic drug. It is 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether.

Some physical constants are:
Molecular weight   184.5
Boiling point at 760 mm Hg 48. 5 C (uncorr.) 
Refractive index n[) 1.2990-1.300520
Specific gravity 25/ 25 C   1.496
Vapor pressure in mm Hg** 20C 238
  25C 295
  30C 367
  35C 450
** Equation for vapor pressure calculation: 
log10 Pvap = A + B/T Where:  A = 8.056
  B = -1664.58
  T = C + 273.16 (Kelvin)
Partition coefficients at 37 C
Water/ gas 0.61 
Blood/ gas  1.43 
Oil/ gas 90.8
Partition coefficients at 25 C - rubber and plastic
Conductive rubber/gas  62.0
Butyl rubber/gas 75.0 
Polyvinyl chloride/ gas 110.0
Polyethylene/ gas ~ 2. 0 
Polyurethane/ gas ~ 1. 4
Polyolefin/ gas ~1. 1 
Butyl acetate/ gas ~ 2. 5
Purity by gas chromatography  >99.9%
Lower limit of flammability in
oxygen or nitrous oxide at
9 joules/ sec. and 23 C


Lower limit of flammability in
oxygen or nitrous oxide at
900 joules/ sec. and 23 C

Greater than useful
concentration in

Isoflurane is a clear, colorless, stable liquid containing no additives or chemical stabilizers. Isoflurane has a mildly pungent, musty, ethereal odor. Samples stored in indirect sunlight in clear, colorless glass for five years, as well as samples directly exposed for 30 hours to a 2 amp, 115 volt, 60 cycle long wave U.V.light were unchanged in composition as determined by gas chromatography. Isoflurane in one normal sodium methoxide-methanol solution, a strong base, for over six months consumed essentially no alkali, indicative of strong base stability. Isoflurane does not decompose in the presence of soda lime (at normal operating temperatures), and does not attack aluminum, tin, brass, iron or copper.

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