Keppra TM (levetiracetam) is an antiepileptic
drug available as 250 mg (blue), 500 mg (yellow) and 750 mg (orange) tablets
for oral administration.
The chemical name of levetiracetam, a single enantiomer, is (-)-(S)-a-ethyl-2-oxo-1-pyrrolidine
acetamide, its molecular formula is C8H14N2O2
and its molecular weight is 170.21. Levetiracetam is chemically unrelated
to existing antiepileptic drugs (AEDs).
Levetiracetam is a white to off-white crystalline powder with a faint
odor and a bitter taste. It is very soluble in water (104.0 g/100 mL).
It is freely soluble in chloroform (65.3 g/100 mL) and in methanol (53.6
g/100 mL), soluble in ethanol (16.5 g/100 mL), sparingly soluble in acetonitrile
(5.7 g/100 mL) and practically insoluble in n-hexane.
Keppra tablets contain the labeled amount of levetiracetam. Inactive
ingredients: colloidal silicon dioxide, corn starch, hydroxypropyl methylcellulose,
magnesium stearate, polyethylene glycol 4000, povidone, talc, titanium
dioxide and coloring agents.
The individual tablets contain the following coloring agents:
250 mg tablets: FD&C Blue No. 2,
500 mg tablets: FD&C Blue No. 2 and yellow iron oxide,
750 mg tablets: FD&C Blue No. 2, FD&C Yellow No. 6 and
red iron oxide.