Liposyn II (Intravenous Fat Emulsion) is a sterile, nonpyrogenic fat
emulsion for intravenous administration. It is supplied in both a 10%
and 20% concentration.
Liposyn II 10% contains 5% safflower oil, 5% soybean oil, up to 1.2%
egg phosphatides added as an emulsifier and 2.5% glycerin in water for
injection. May contain sodium hydroxide for pH adjustment. pH 8.0 (6.0
9.0). Liposyn II 10% has an osmolarity of 276 mOsmol/liter (actual).
The total caloric value of Liposyn II 10% including fat, phospholipid
and glycerol is 1.1 kcal/mL. Of this total, approximately 0.6 kcal/mL
is supplied by linoleic acid.
Liposyn II 20% contains 10% safflower oil, 10% soybean oil, 1.2% egg
phosphatides and 2.5% glycerin in water for injection. May contain sodium
hydroxide for pH adjustment, pH 8.3 (6.0 - 9.0). Liposyn II 20% has an
osmolarity of 258 mOsmol/liter (actual). The total caloric value of Liposyn
II 20% including fat, phospholipid and glycerol is 2.0 kcal/mL. Of this
total, approximately 1.2 kcal/mL are supplied by linoleic acid.
Both Liposyn II 10% and Liposyn II 20% contain emulsified fat particles
of approximately 0.4 micron in diameter, similar to naturally occurring
Safflower oil and Soybean Oil, USP are mixtures of neutral triglycerides.
R1C-, R2C- and R3C- are saturated and
unsaturated fatty acid residues. The major component fatty acids of the
50/50 safflower/soybean oil mixture are approximately 65.8% linoleic,
17.7% oleic, 8.8% palmitic, 3.4% stearic, and 4.2% linolenic acid. These
fatty acids have the following chemical formulas:
Egg phosphatides, purified, are primarily a mixture of naturally occurring
phospholipids which are isolated from the egg yolk.
R1C- and R2C- are the same saturated and unsaturated
fatty acid residues that abound in neutral fats. R3 is primarily
either the choline (HOCH2CH2CH3)3
ester or ethanolamine (HOCH2CH2NH2) ester
of phosphoric acid (H3PO4).
Glycerin, USP is chemically designated C3H8O3
and is a clear colorless, hygroscopic syrupy liquid.