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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (M's) » Melphalan


ALKERANÒ (melphalan) 2 mg Scored Tablets

ALKERAN melphalan should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents Severe bone marrow suppression with resulting infection or bleeding may occur Melphalan is leukemogenic in humans Melphalan produces chromosomal aberrations in vitro and in vivo and therefore, should be considered potentially mutagenic in humans.

ALKERAN (melphalan) also known as L-phenylalanine mustard, phenylalanine mustard, L-PAM or L-sarcolysin, is a phenylalanine derivative of nitrogen mustard. Melphalan is a bifunctional alkylating agent which is active against selective human neoplastic diseases. It is known chemically as 4-[bis(2-chloroethyl) amino]-L-phenylalanine. The molecular formula is C13H18Cl2N2O2 and the molecular weight is 305.20.

Melphalan is the active L-isomer of the compound and was first synthesized in 1953 by Bergel and Stock; the D isomer, known as medphalan, is less active against certain animal tumors, and the dose needed to produce effects on chromosomes is larger than that required with the L-isomer. The racemic (DL-) form is known as merphalan or sarcolysin.

Melphalan is practically insoluble in water and has a pKa1 of ~2.5.

ALKERAN (melphalan) is available in tablet form for oral administration. Each scored tablet contains 2 mg melphalan and the inactive ingredients lactose, magnesium stearate, potato starch, povidone, and sucrose.

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