The active ingredient
in ROWASA® Rectal Suspension Enema, a disposable (60 mL) unit,
is mesalamine, also known as 5-aminosalicylic acid
(5-ASA). Chemically, mesalamine is 5-amino-2-hydroxybenzoic acid.
The empirical formula
is C7H7NO3, representing a molecular
weight of 153.14.
Each rectal suspension
contains 4 grams of mesalamine. In addition to mesalamine the preparation
contains the inactive ingredients carbomer 934P, edetate disodium,
purified water and xanthan
gum. Sodium benzoate
is added as a preservative.
The disposable unit consists
of an applicator
tip protected by a polyethylene
cover and lubricated with USP white
petrolatum. The unit has
a one-way valve to prevent back
flow of the dispensed product.