Naloxone hydrochloride, a narcotic antagonist, is a synthetic congener
of oxymorphone. In structure it differs from oxymorphone in that the methyl
group on the nitrogen atom is replaced by an allyl group.
It has the following molecular formula C19H21NO4HCl
with a molecular weight of 363.84.
The chemical name for naloxone hydrochloride is: (-)-17-Allyl-4, 5a-epoxy-3,14-dihydroxymorphinan-6-one
Naloxone hydrochloride occurs as a white to slightly off-white powder,
and is soluble in water, in dilute acids, and in strong alkali; slightly
soluble in alcohol; practically insoluble in ether and in chloroform.
Naloxone Hydrochloride Injection is a sterile solution intended for intramuscular,
subcutaneous or intravenous use. Each mL contains naloxone hydrochloride
400 micrograms (0.4 mg), sodium chloride 8.6 mg, methylparaben 1.8 mg
and propylparaben 0.2 mg in Water for Injection. pH 3.0-4.5; hydrochloric
acid and/or sodium hydroxide used, if needed, for pH adjustment. Sealed