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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (N's) » Naloxone


Naloxone hydrochloride, a narcotic antagonist, is a synthetic congener of oxymorphone. In structure it differs from oxymorphone in that the methyl group on the nitrogen atom is replaced by an allyl group.

It has the following molecular formula C19H21NO4HCl with a molecular weight of 363.84.

The chemical name for naloxone hydrochloride is: (-)-17-Allyl-4, 5a-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride

Naloxone hydrochloride occurs as a white to slightly off-white powder, and is soluble in water, in dilute acids, and in strong alkali; slightly soluble in alcohol; practically insoluble in ether and in chloroform.

Naloxone Hydrochloride Injection is a sterile solution intended for intramuscular, subcutaneous or intravenous use. Each mL contains naloxone hydrochloride 400 micrograms (0.4 mg), sodium chloride 8.6 mg, methylparaben 1.8 mg and propylparaben 0.2 mg in Water for Injection. pH 3.0-4.5; hydrochloric acid and/or sodium hydroxide used, if needed, for pH adjustment. Sealed under nitrogen.

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