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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (N's) » Nefazodone



DESCRIPTION

Nefazodone is an antidepressant for oral administration with a chemical structure unrelated to selective serotonin reuptake inhibitors, tricyclics, tetracyclics, or monoamine oxidase inhibitors (MAOI).

Nefazodone hydrochloride is a synthetically derived phenylpiperazine antidepressant. The chemical name for nefazodone hydrochloride is 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ether-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one monohydrochloride. The molecular formula is C25H32ClN5O2HCl, which corresponds to a molecular weight of 506.5.

Nefazodone is a nonhygroscopic, white crystalline solid. It is freely soluble in chloroform, soluble in propylene glycol, and slightly soluble in polyethylene glycol and water.

Serzone is supplied as hexagonal tablets containing 100 mg, 150 mg, 200 mg, or 250 mg of nefazodone hydrochloride and the following inactive ingredients: microcrystalline cellulose, povidone, sodium starch glycolate, colloidal silicon dioxide, magnesium stearate, and iron oxides (red and/or yellow) as colorants.

CATEGORIES, BRAND NAMES

CATEGORIES: Depression; FDA Class 1S ("Standard Review"); FDA Approved 1994 Dec; Pregnancy Category C; Top 200 Drugs

FDA Drug Classes: Antidepressants

BRAND NAMES:

BRAND NAMES: Nefadar; Serzone; Serzonil

FOREIGN BRAND AVAILABILITY:
Nefadar (Germany)
Serzonil (Israel)

COST OF THERAPY: $232.20 (Depression; Serzone Tablet; 150 mg; 2/day; 90 days)





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