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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (N's) » Nelfinavir Mesylate


(nelfinavir mesylate)

VIRACEPT is indicated for the treatment of HIV infection when antiretroviral therapy is warranted. This indication is based on surrogate marker changes in patients who received VIRACEPT in combination with nucleoside analogues or alone for up to 24 weeks. At present, there are no results from controlled trials evaluating the effect of therapy with VIRACEPT on clinical progression of HIV infection, such as survival or the incidence of opportunistic infections.

VIRACEPT® (nelfinavir mesylate) is an inhibitor of the human immunodeficiency virus (HIV) protease. VIRACEPT Tablets are available for oral administration as a light blue, capsule-shaped tablet in a 250 mg strength (as nelfinavir free base). Each tablet also contains the following inactive ingredients: calcium silicate, crospovidone, magnesium stearate and FD&C blue #2 powder. VIRACEPT Oral Powder is available for oral administration in a 50 mg/g strength (as nelfinavir free base) in bottles. The oral powder also contains the following inactive ingredients: microcrystalline cellulose, maltodextrin, dibasic potassium phosphate, crospovidone, hydroxypropyl methylcellulose, aspartame, sucrose palmitate, and natural and artificial flavor. The chemical name for nelfinavir mesylate is [3S - [2(2S*, 3S*), 3 alpha,4a beta,8a beta]] - N - (1,1-dimethylethyl) decahydro - 2 - [2 - hydroxy - 3 - [(3 - hydroxy - 2 - methylbenzoyl)amino] - 4 - (phenylthio)butyl] - 3 - isoquinolinecarboxamide mono - methanesulfonate (salt) and the molecular weight is 663.90 (567.79 as the free base).

Nelfinavir mesylate is a white to off-white amorphous powder, slightly soluble in water at pH less than or equal to 4 and freely soluble in methanol, ethanol, isopropanol and propylene glycol.

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