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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (N's) » Nitroglycerin



DESCRIPTION

Note: The information in this monograph pertains to the IV form of nitroglycerin (except where noted otherwise).

IV: FOR INTRAVENOUS USE ONLY: NOT FOR DIRECT INTRAVENOUS INJECTION (MUST BE DILUTED), NITROGLYCERIN MUST BE DILUTED IN DEXTROSE 5% INJECTION, USP OR SODIUM CHLORIDE (0.9%) INJECTION, USP BEFORE INTRAVENOUS ADMINISTRATION. THE ADMINISTRATION SET USED FOR INFUSION MAY AFFECT THE AMOUNT OF NITROGLYCERIN DELIVERED TO THE PATIENT. (SEE WARNINGS and DOSAGE AND ADMINISTRATION SECTIONS.)

CAUTION: SEVERAL PREPARATIONS OF NITROGLYCERIN INJECTION, USP ARE AVAILABLE. THEY DIFFER IN CONCENTRATION AND/OR VOLUME PER VIAL. WHEN SWITCHING FROM ONE PRODUCT TO ANOTHER, ATTENTION MUST BE PAID TO THE DILUTION AND DOSAGE AND ADMINISTRATION INSTRUCTIONS.

Nitroglycerin injection is a clear, practically colorless additive solution for intravenous infusion after dilution. Each milliliter contains 5 mg nitroglycerin and 45 mg propylene glycol.

The solution is sterile, nonpyrogenic, and nonexplosive. Nitroglycerin, an organic nitrate, is a vasodilator. The chemical name for nitroglycerin is 1,2,3 propanetriol trinitrate.

Extended Release Oral Tablets: Each 2.6 mg tablet for oral administration contains 2.6 mg nitroglycerin in extended-release form with light green granules containing corn-starch, D&C yellow #10 lake and iron oxide. Each 6.5 mg tablet for oral administration contains 6.5 mg nitroglycerin in extended-release form with light orange granules containing cornstarch, D&C yellow #10 lake, FD&C yellow #6 lake, iron oxide and povidone.

Sublingual Tablets: This form is manufactured by a process which prevents the migration of nitroglycerin by adding the nonvolatile fixing agent polyethylene glycol 3350. This stabilized formulation has been shown to be more stable and more uniform than conventional molded tablets. Nitroglycerin sublingual tablets contain 0.15 mg (1/400 grain), 0.3 mg (1/200 grain), 0.4 mg (1/150 grain) and 0.6 (1/100 grain) nitroglycerin. Also contains lactose, NF; polyethylene glycol 3350, NF; sucrose, NF.

Ointment: Contains 2% nitroglycerin ointment and lactose in a lanolin and white petrolatum base. Each inch, as squeezed from the tube, contains approximately 15 mg nitroglycerin.

Lingual Aerosol Spray: Nitroglycerin spray is a metered dose aerosol containing nitroglycerin in propellants (dichlorodifluoromethane and dichlorotetrafluoroethane). Each metered dose delivers 0.4 mg of nitroglycerin per spray emission. This product delivers nitroglycerin in the form of spray droplets onto or under the tongue. Inactive ingredients are: caprylic/capric/diglycereryl succinate, ether, flavors.

Transdermal Delivery System: This unit is designed to provide continuous controlled release of nitroglycerin through intact skin. the rate of release is linearly dependent upon the area of the applied system; each cm2 of applied system delivers approximately 0.02 mg of nitroglycerin per hour. Thus, 3.3, 6.7, 13.3 and 20 cm2 system delivers approximately 0.1, 0.2. 0.4. and 0.6 mg of nitroglycerin per hour, respectively.

The remainder of nitroglycerin in each system serves as a reservoir and is not delivered in normal use. After 12 hours, for example, each system has delivered about 6% of its original content of nitroglycerin.

This transdermal delivery system contains nitroglycerin in a hypoallergenic, medical grade, acrylic-based polymer adhesive. Each patch is packaged in foil/polymer film laminate.

Prior to use, a protective peel strip is removed from the adhesive surface. Following use, the patch should be discarded in a manner that prevents accidental application or ingestion by children or others.

CATEGORIES, BRAND NAMES

CATEGORIES: Angina pectoris; Heart failure associated with myocardial infarction; Hypertension, perioperative; Surgery, adjunct; Pregnancy Category C; FDA Approved 1981 Oct; Top 200 Drugs; WHO Formulary

FDA Drug Classes: Antianginals; Antihypertensives; Coronary Vasodilators; Homeopathic Products

BRAND NAMES:

BRAND NAMES: Anginine; Angised; Cardinit; Corditrine; Coro-Nitro; Deponit; Deponit 5; Deponit-5; Deponit TTS 5; Deponit TTS 10; Gilustenon; Glyceryl; Lenitral; Mi-Trates; Minitran; Myovin; Natirose; Niong Retard; Nitradisc; Nitradisc Pad; Nitradisc TTS; Nit-Ret; Nitrek; Nitriderm TTS; Nitro; Nitro Retard; Nitrobaat; Nitro-Bid; Nitrobid; Nitrobid Oint; Nitrocap T.D.; Nitrocerin; Nitrocine; Nitrocine 5; Nitrocontin; Nitrocontin Continus; Nitrocor; NitroCor; Nitrocot; Nitroderm TTS; Nitroderm TTS Ext; Nitro-Dur; Nitro-Dur 5; Nitro-Dur 10; Nitro Dur TTS; Nitrodyl; Nitrodyl TTS; Nitro-Gesanit Retard; Nitrogard-SR; Nitro-M-Bid; Nitro Mack Retard; Nitromack Retard; Nitro-Mack Retard; Nitromex; Nitromint; Nitromint Aerosol; Nitromint Retard; Nitro-Par; Nitropatch; Nitroprol; Nitro-Time; Nitroderm TTS-5; Nitrodisc; Nitro-Pflaster; Nitrogard; Nitroglin; Nitroglyn; Nitrol; Nitrolin; Nitrolingual; Nitrolingual Spray; Nitrolong; Nitronal; Nitrong; Nitrong Retard; Nitrong-SR; Nitropen; Nitroplast; Nitropront; Nitroprontan; Nitrorectal; Nitrorex; Nitro Rorer; Nitrospan; Nitrostat; Nitrovis; Nitrozell Retard; NTS; NTG; Nysconitrine; Percutol; Percutol Oint.; Ratiopharm; Suscard; Sustac; Transderm-Nitro; Transiderm; Transiderm Nitro; Tridil; Vasolator; Venitrin; Willong
(Foreign Brand names outside U.S. in italics)

FOREIGN BRAND AVAILABILITY:
Anginine (Australia; New-Zealand)
Cardinit (Mexico)
Corditrine (France)
Coro-Nitro (Germany)
Deponit 5 (Thailand)
Deponit-5 (Korea)
Deponit TTS 5 (Israel)
Deponit TTS 10 (Israel)
Gilustenon (Germany)
Lenitral (France; Hong-Kong; Malaysia)
Myovin (India)
Niong Retard (Switzerland)
Nitradisc (Australia; Costa-Rica; Denmark; Dominican-Republic; El-Salvador; Germany; Guatemala; Honduras; Hong-Kong; Indonesia; Mexico; Nicaragua; Norway; Panama; Philippines; Portugal; South-Africa; Spain; Thailand)
Nitradisc Pad (New-Zealand)
Nitradisc TTS (Greece)
Nit-Ret (Czech-Republic)
Nitriderm TTS (France; Germany)
Nitro Retard (Bulgaria; Norway; Sweden)
Nitrobaat (Belgium; Netherlands)
Nitrobid (Canada; Japan)
Nitrobid Oint (New-Zealand)
Nitrocerin (Greece)
Nitrocine 5 (Bahrain; Cyprus; Egypt; Iran; Iraq; Israel; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic-Of-Yemen; Saudi-Arabia; Syria; United-Arab-Emirates)
Nitrocontin (Benin; Burkina-Faso; Ethiopia; Gambia; Ghana; Guinea; Ireland; Ivory-Coast; Kenya; Liberia; Malawi; Mali; Mauritania; Mauritius; Morocco; Niger; Nigeria; Senegal; Seychelles; Sierra-Leone; South-Africa; Sudan; Taiwan; Tanzania; Tunia; Uganda; Zambia; Zimbabwe)
Nitrocontin Continus (Bahrain; Cyprus; Egypt; England; India; Iran; Iraq; Israel; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic-Of-Yemen; Saudi-Arabia; Syria; United-Arab-Emirates)
Nitrocor (Italy; Portugal)
NitroCor (New-Zealand)
Nitroderm TTS (Austria; Bahamas; Bahrain; Barbados; Belgium; Belize; Benin; Bermuda; Bulgaria; Burkina-Faso; Curacao; Cyprus; Egypt; Ethiopia; Gambia; Germany; Ghana; Guinea; Guyana; Hong-Kong; India; Indonesia; Iran; Iraq; Israel; Israel; Italy; Ivory-Coast; Jamaica; Jordan; Kenya; Korea; Kuwait; Lebanon; Liberia; Libya; Malawi; Malaysia; Mali; Mauritania; Mauritius; Morocco; Netherland-Antilles; New-Zealand; Niger; Nigeria; Oman; Portugal; Puerto-Rico; Qatar; Republic-Of-Yemen; Saudi-Arabia; Senegal; Seychelles; Sierra-Leone; South-Africa; South-Africa; Spain; Sudan; Surinam; Switzerland; Syria; Taiwan; Tanzania; Thailand; Trinidad; Tunia; Uganda; United-Arab-Emirates; Zambia; Zimbabwe)
Nitroderm TTS Ext (Czech-Republic)
Nitro-Dur 5 (Israel)
Nitro-Dur 10 (Israel)
Nitro Dur TTS (Switzerland)
Nitrodyl (Greece)
Nitrodyl TTS (Greece)
Nitro-Gesanit Retard (Germany)
Nitrogard-SR (Canada)
Nitro-M-Bid (Belgium)
Nitro Mack Retard (Austria; Bahamas; Bahrain; Barbados; Belize; Bermuda; Costa-Rica; Curacao; Cyprus; Czech-Republic; Dominican-Republic; Ecuador; Egypt; El-Salvador; Germany; Greece; Guyana; Honduras; Iran; Iraq; Israel; Jamaica; Jordan; Kuwait; Lebanon; Libya; Malaysia; Netherland-Antilles; Oman; Panama; Puerto-Rico; Qatar; Republic-Of-Yemen; Saudi-Arabia; Surinam; Switzerland; Syria; Trinidad; United-Arab-Emirates)
Nitromack Retard (Hong-Kong; India; Indonesia)
Nitro-Mack Retard (Taiwan; Thailand)
Nitromex (Denmark; Finland; Norway; Sweden)
Nitromint (Hungary; Switzerland)
Nitromint Aerosol (Benin; Burkina-Faso; Ethiopia; Gambia; Ghana; Guinea; Ivory-Coast; Kenya; Liberia; Malawi; Mali; Mauritania; Mauritius; Morocco; Niger; Nigeria; Senegal; Seychelles; Sierra-Leone; South-Africa; Sudan; Tanzania; Tunia; Uganda; Zambia; Zimbabwe)
Nitromint Retard (Bahamas; Bahrain; Barbados; Belize; Bermuda; Curacao; Cyprus; Egypt; Guyana; Iran; Iraq; Israel; Jamaica; Jordan; Kuwait; Lebanon; Libya; Netherland-Antilles; Oman; Puerto-Rico; Qatar; Republic-Of-Yemen; Saudi-Arabia; Surinam; Syria; Trinidad; United-Arab-Emirates)
Nitropatch (Korea)
Nitroprol (Belgium)
Nitroderm TTS-5 (Colombia; Mexico)
Nitro-Pflaster (Germany)
Nitroglin (Germany)
Nitrolingual Spray (Australia; New-Zealand)
Nitrolong (Switzerland)
Nitrong Retard (Austria; Greece)
Nitrong-SR (Canada)
Nitropen (Japan)
Nitroplast (Spain)
Nitropront (Finland)
Nitroprontan (Argentina)
Nitrorectal (Germany)
Nitro Rorer (Germany)
Nitrovis (Israel)
Nitrozell Retard (Austria; Netherlands)
Nysconitrine (Belgium)
Percutol (Ireland)
Percutol Oint. (England)
Ratiopharm (Germany)
Suscard (England)
Sustac (Bahamas; Bahrain; Barbados; Belize; Bermuda; Curacao; Cyprus; Egypt; England; Guyana; Iran; Iraq; Israel; Jamaica; Jordan; Kuwait; Lebanon; Libya; Netherland-Antilles; Oman; Puerto-Rico; Qatar; Republic-Of-Yemen; Saudi-Arabia; Surinam; Syria; Trinidad; United-Arab-Emirates)
Transiderm Nitro (Australia; Denmark; Finland; Netherlands; Norway; Sweden)
Vasolator (Japan)
Venitrin (Italy)
Willong (Thailand)

COST OF THERAPY: 43.25 (Angina; Capsule; 6.5 mg; 3/day; 365 days)





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