Norepinephrine (sometimes referred to as l-arterenol/Levarterenol
or l-norepinephrine) is a sympathomimetic amine which differs from
epinephrine by the absence of a methyl group on the nitrogen atom.
Norepinephrine Bitartrate is(-)-a-(aminomethyl)-3,4-dihydroxybenzyl
alcohol tartrate (1:1) (salt) monohydrate
Norepinephrine Bitartrate Injection is a sterile, nonpyrogenic concentrated
solution of the drug in water for injection. It is intended for intravenous
administration only after dilution in dextrose containing solutions (see
DOSAGE AND ADMINISTRATION).
Each mL of norepinephrine bitartrate 1:1,000 contains the equivalent
of 1 mg norepinephrine base; sodium Chloride 8.2 mg; sodium metabisulfite
0.46 mg added as an antioxidant; citric acid, anhydrous 1.3 mg and sodium
citrate, dihydrate 0.9 mg added as buffers. The pH is 3.6 (3.0 to 4.5).
Norepinephrine Bitartrate Injection, USP, is oxygen sensitive.
This solution contains no bacteriostat or antimicrobial agent. When smaller
doses or amounts are required the unused portion should be discarded.