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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (P's) » Pravastatin


Pravastatin sodium is one of a new class of lipid-lowering compounds, the HMG-CoA reductase inhibitors, which reduce cholesterol biosynthesis. These agents are competitive inhibitors of 3-hydroxy-3-methylglutaryl-co-enzyme A (HMG-CoA) reductase, the enzyme catalyzing the early rate-limiting step in cholesterol biosynthesis, conversion of HMG-CoA to mevalonate.

Pravastatin sodium is designated chemically as 1-Naphthalene-heptanoic acid, 1,2,6,7,8,8a-hexahydro-b, d,6-trihydroxy-2-methyl -8-(2-methyl -1- oxobutoxy)-, monosodium salt,[1S-[1a(bS*, d S*),2a,6a,8b(R*),8aa]]-. Formula C23H35NaO7, Molecular Weight is 446.52.

Pravastatin sodium is an odorless, white to off-white, fine or crystalline powder. It is a relatively polar hydrophilic compound with a partition coefficient (octanol/water) of 0.59 at a pH of 7.0. It is soluble in methanol and water (>300 mg/ml), slightly soluble in isopropanol, and practically insoluble in acetone, acetonitrile, chloroform, and ether.

Pravachol is available for oral administration as 10 mg, 20 mg and 40 mg tablets. Inactive ingredients include: croscarmellose sodium, lactose, magnesium oxide, magnesium stearate, microcrystalline cellulose, and povidone. The 10 mg tablet also contains Red Ferric Oxide, the 20 mg tablet also contains Yellow Ferric Oxide, and the 40 mg tablet also contains Green Lake Blend (mixture of D&C Yellow No. 10-Aluminum Lake and FD&C Blue No. 1-Aluminum Lake).


CATEGORIES: Hypercholesterolemia; Hyperlipidemia; Hyperlipoproteinemia; Pregnancy Category X; FDA Class 1C ("Little or No Therapeutic Advantage"); FDA Approved 1991 Oct; Top 200 Drugs

FDA Drug Classes: Hyperlipidemia


BRAND NAMES: Elisor; Lipidal; Lipostat; Liprevil; Mevalotin; Prava; Pravachol; Pravacol; Pravaselect; Pravasin; Pravasine; Pravastatin Natrium "Mayrho Fer"; Selectin; Selektine; Selipran; Vasten
(Foreign Brand names outside U.S. in italics)

Elisor (France)
Lipidal (Israel)
Lipostat (England; Ireland; Israel; New-Zealand; Philippines)
Liprevil (Germany)
Mevalotin (Germany; Indonesia; Japan; Korea; Taiwan; Thailand)
Prava (Slovenia)
Pravacol (Portugal)
Pravaselect (Italy)
Pravasin (Germany)
Pravasine (Belgium)
Pravastatin Natrium "Mayrho Fer" (Austria)
Selectin (Italy)
Selektine (Netherlands)
Selipran (Switzerland)
Vasten (France)

COST OF THERAPY: $824.90 (Hypercholesterolemia; Pravachol Tablet; 10 mg; 1/day; 365 days)

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