PROMETHAZINE HYDROCHLORIDE AND
DEXTROMETHORPHAN HYDROBROMIDE SYRUP
Each 5 mL (one teaspoonful), for oral
contains: Dextromethorphan hydrobromide 15 mg; promethazine hydrochloride
6.25 mg. Alcohol 7%.
Inactive Ingredients: Citric acid, corn
syrup, FD& C Yellow #6, flavor, methylparaben, propylene glycol,
propylparaben, purified water, saccharin sodium, sodium
benzoate, sodium citrate.
Dextromethorphan hydrobromide is a salt
of the methyl ether
of the dextrorotatory isomer
of levorphanol, a narcotic
analgesic. It is chemically designated as 3-methoxy-1,7-methyl-9a,13a,14a-morphinan
Dextromethorphan hydrobromide occurs as white
crystals sparingly soluble in water
and freely soluble in
alcohol. It has a molecular weight
of 370.33, and a molecular formula
of C18H25NO HBr H2O.
Promethazine is a racemic
compound. Promethazine hydrochloride, a phenothiazine derivative,
is chemically designated as (±)-10-[2-(Dimethyl-amino)propyl]
occurs as a white to faint
yellow, practically odorless, crystalline
powder which slowly oxidizes
and turns blue on prolonged
exposure to air. It is soluble
in water and freely soluble
in alcohol. It has a molecular weight
of 320.89, and a molecular formula
of C17H20N2S HCl.