Each 5 mL (one teaspoonful), for oral administration contains: Promethazine
hydrochloride 6.25 mg; phenylephrine hydrochloride 5 mg, Alcohol 7%.
Inactive Ingredients: Citric acid, FD& C yellow #6, flavor,
methyl- paraben, propylene glycol, propyl- paraben, purified water, saccharin
sodium, sodium benzoate, sodium citrate, sucrose. Promethazine hydrochloride,
a phenothiazine derivative, is chemically designated as (±)-10-[2-(Dimethylamino)
propyl] phenothiazine monohydrochloride.
Promethazine hydrochloride occurs as a white to faint yellow, practically
odorless, crystalline powder which slowly oxidizes and turns blue on prolonged
exposure to air. It is soluble in water and freely soluble in alcohol.
It has a molecular weight of 320.89, and a molecular formula of C17H20N2S
Phenylephrine hydrochloride is a sympathomimetic amine salt which is
chemically designated as (-)- m- Hydroxy-a-[(methylamino)
methyl] benzyl alcohol hydrochloride. It occurs as white or nearly white
crystals, having a bitter taste. It is freely soluble in water and alcohol.
Phenylephrine hydrochloride is subject to oxidation and must be protected
from light and air. It has a molecular weight of 203.67, and a molecular
formula of C9H13NO2 HCl.