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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (Q's) » Quinapril



WARNING

Use In Pregnancy: When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, quinapril HCl should be discontinued as soon as possible. (See WARNINGS, Fetal/Neonatal Morbidity and Mortality).


DESCRIPTION

Quinapril hydrochloride is the hydrochloride salt of quinapril, the ethyl ester of a nonsulfhydryl, angiotensin-converting enzyme (ACE) inhibitor, quinaprilat.

Quinapril hydrochloride is chemically described as (3S-(2(R*(R*)), 3R*))-2-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,2,3, 4-tetrahydro-3-isoquinolinecarboxylic acid, monohydrochloride. Its empirical formula is C25H30N2O5·HCl.

Quinapril hydrochloride is a white to off-white amorphous powder that is freely soluble in aqueous solvents.

Accupril tablets contain 5 mg, 10 mg, 20 mg, or 40 mg of quinapril for oral administration. Each tablet also contains candelilla wax, crospovidone, gelatin, lactose, magnesium carbonate, magnesium stearate, synthetic red iron oxide, and titanium dioxide.

CATEGORIES, BRAND NAMES

CATEGORIES: Heart failure, congestive; Hypertension, essential; Pregnancy Category D; FDA Class 1C ("Little or No Therapeutic Advantage"); FDA Approved 1991 Nov; Top 200 Drugs



FDA Drug Classes: ACE Inhibitors; Antihypertensives

BRAND NAMES:

BRAND NAMES: Accupril; Accuprin; Accupro; Accupron; Acequin; Acuitel; Acuprel; Acupril; Asig; Korec; Quinazil
(Foreign Brand names outside U.S. in italics)

FOREIGN BRAND AVAILABILITY:
Accuprin (Italy)
Accupro (Austria; Czech-Republic; Denmark; England; Finland; Sweden; Switzerland)
Accupron (Greece)
Acequin (Italy)
Acuitel (France)
Acuprel (Spain)
Acupril (Mexico; Netherlands)
Asig (Australia)
Korec (France)
Quinazil (Italy)

COST OF THERAPY: 346.70 (Hypertension; Tablet; 10 mg; 1/day; 365 days)





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