EVISTA® (raloxifene hydrochloride) is a selective
estrogen receptor modulator (SERM) that belongs to the benzothiophene
class of compounds.
The chemical designation
is methanone, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]-[
4-[ 2-( 1-piperidinyl) ethoxy] phenyl]-, hydrochloride. Raloxifene
hydrochloride (HCl) has the empirical
HCl, which corresponds to a molecular weight
of 510.05. Raloxifene HCl is an off-white to pale-yellow solid
that is very slightly soluble in water.
EVISTA is supplied in a tablet
for oral administration.
Each EVISTA tablet contains
60 mg of raloxifene HCl,
which is the molar equivalent of 55.71 mg
of free base. Inactive ingredients include anhydrous lactose, carnauba
wax, crospovidone, FD& C Blue No. 2 aluminum
lake, hydroxypropyl methylcellulose, lactose
stearate, modified pharmaceutical
glycol, polysorbate 80, povidone, propylene glycol, and titanium